مرور Volume 21, Issue 5 بر اساس تاریخ انتشار
در حال نمایش موارد 1 - 10 از 10
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Insulin glargine affects the expression of Igf-1r, Insr, and Igf-1 genes in colon and liver of diabetic rats
(Mashhad University of Medical Sciences, 2018-05-01)Objective(s): The mitogenic effect of the analogous insulin glargine is currently under debate since several clinical studies have raised the possibility that insulin glargine treatment has a ...
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Long-term administration of olanzapine induces adiposity and increases hepatic fatty acid desaturation protein in female C57BL/6J mice
(Mashhad University of Medical Sciences, 2018-05-01)Objective(s): Weight gain and metabolic disturbances such as dyslipidemia, are frequent side effects of second-generation antipsychotics, including olanzapine. This study examined the metabolic ...
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The role of nanoliposome bilayer composition containing soluble leishmania antigen on maturation and activation of dendritic cells
(Mashhad University of Medical Sciences, 2018-05-01)Objective(s): Dendritic cells (DCs) play a critical role in activation of T cell responses. Induction of type1 T helper (Th1) immune response is essential to generate protective immunity against ...
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The effects of bone marrow-derived mesenchymal stem cells on ovalbumin-induced allergic asthma and cytokine responses in mice
(Mashhad University of Medical Sciences, 2018-05-01)Objective(s): Allergic Asthma is an inflammatory disease of the lungs that is characterized by increased infiltration of leukocytes into the airways, limiting the respiratory function. Studies ...
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Cyclooxygenase inhibitors combined with deuterium-enriched water augment cytotoxicity in A549 lung cancer cell line via activation of apoptosis and MAPK pathways
(Mashhad University of Medical Sciences, 2018-05-01)Objective(s): Combination chemotherapy is a rational strategy to increase patient response and tolerability and to decrease adverse effects and drug resistance. Recently, the use of non-steroidal ...
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Down-regulation of microRNA-23b aggravates LPS-induced inflammatory injury in chondrogenic ATDC5 cells by targeting PDCD4
(Mashhad University of Medical Sciences, 2018-05-01)Objective(s): Osteoarthritis (OA), characterized by degradation of articular cartilage, is a leading cause of disability. As the only cell type present in cartilage, chondrocytes play curial roles ...
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The effect of down-regulation of CCL5 on lipopolysaccharide-induced WI-38 fibroblast injury: a potential role for infantile pneumonia
(Mashhad University of Medical Sciences, 2018-05-01)Objective(s): Aberrant expression of CCL5 has been found in several kinds of inflammatory diseases, and the roles of CCL5 in these diseases have also been reported. However, the role of CCL5 in ...
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A review of the effects of Capsicum annuum L. and its constituent, capsaicin, in metabolic syndrome
(Mashhad University of Medical Sciences, 2018-05-01)Objective(s): Metabolic syndrome, a coexisting of high blood glucose, obesity, dyslipidemia and hypertension, is an important risk factor for cardiovascular disease occurrence and mortality. ...
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Metformin-attenuated sepsis-induced oxidative damages: a novel role for metformin
(Mashhad University of Medical Sciences, 2018-05-01)Objective(s): Sepsis can result in severe organ injury by provoking inflammatory cascades and oxidative stress. Several studies are currently underway to find a drug with anti-inflammatory effects ...
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An answer to colon cancer treatment by mesenchymal stem cell originated from adipose tissue
(Mashhad University of Medical Sciences, 2018-05-01)Objective(s): Colon cancer is risen up with its complex mechanism that directly impacts on its treatment as well as its common prevalence. Mesenchymal stem cells (MSCs) have been considered as a ...



