Importance of Neutrophil/Lymphocyte Ratio in Prediction of PSA Recurrence after Radical Prostatectomy

Abstract

<b>Background:</b> The aim of this study was to research the importance of the neutrophil to lymphocyte ratio(NLR) in prediction of PSA recurrence after radical prostatectomy, which has not been reported so far. Materialsand <br/><b>Methods</b>: The data of 175 patients who were diagnosed with localised prostate cancer and underwentretropubic radical prostatectomy was retrospectively examined. Patient pre-operative hemogram parameters ofneutrophil count, lymphocyte count and NLR were assessed. The patients whose PSAs were too low to measureafter radical prostatectomy in their follow-ups, and then had PSAs of 0,2 ng/mL were considered as patients withPSA recurrence. Patients with recurrence made up Group A and patients without recurrence made up Group B.<br/><b>Results</b>: In terms of the power of NLR value in distinguishing recurrence, the area under OCC was statisticallysignificant (p<0.001) .The value of 2.494 for NLR was found to be a cut-off value which can be used in orderto distinguish recurrence according to Youden index. According to this, patients with a higher NLR value than2.494 had higher rates of PSA recurrence with 89.7% sensitivity and 92.6% specificity. <br/><b>Conclusions</b>: There arecertain parameters used in order to predict recurrence with today’s literature data.We think that because NLRis easy to use in clinics and inexpensive, and also has high sensitivity and specificity values, it has the potentialto be one of the parameters used in order to predict biochemical recurrence in future.