Could the Platelet-to-Lymphocyte Ratio be a Novel Marker for Predicting Invasiveness of Cervical Pathologies?

Abstract

Purpose: To determine whether the preoperative platelet to lymphocyte ratio (PLR) could predict invasivenessof cervical pathologies. Materials and <br/><b>Methods</b>: Patients with preinvasive and invasive diseases were reviewedretrospectively, over a nine-year period, 2005-2014. The pathological records and completed blood counts ofthe patients were collected and recorded in the SPSS program. Patients were divided in two groups, preinvasiveand invasive. <br/><b>Results</b>: The median PLR was significantly higher in the invasive group than in the preinvasivegroup (p=0.03). There was a correlation between invasion of cervical cancer and white blood cell count, redcell distributing width (RDW), neutrophil-lymphocyte ratio (NLR), and PLR. <br/><b>Conclusions</b>: This study showedthat patients with uterine cervical cancer may present with leukocytosis, increased RDW, NLR and PLR. Thesecheap and easily available parameters, especially PLR, may provide useful information about the invasivenessof cervical lesions.