Effect of Botulinum Toxin A on Proliferation and Apoptosis inthe T47D Breast Cancer Cell Line

Abstract

The present study was performed to assess the activity of the botulinum toxin A on breast cancer cells. TheT47D cell line was exposed to diverse concentrations of the botulinum toxin A and cell viability and apoptosiswere estimated using MTT and propidium iodine/annexin V methods, respectively. Botulinum toxin A exertedgreater cytotoxic activity in T47D cells in comparison with MCF10A normal cells; this appeared to be viaapoptotic processes caspase-3 and -7. In conclusion, botulinum toxin A induces caspase-3 and -7 dependentapoptotic processes in the T47D breast cancer cell line.