Chemoprevention by Triticum Aestivum of Mouse Skin Carcinogenesis Induced by DMBA and Croton Oil - Association with Oxidative Status

Abstract

Chemopreventive action of wheat grass (Triticum astivum) leaf extract in Swiss albino mice was evaluated.Oral administration of wheat grass leaf extract at a dose level of 20 ml/kg body weight per day at pre, peri, andpost-initional phases and in combination group, caused significant variation in tumour incidence and tumouryield as compared to the control group. Moreover, the average latent period was significantly increased from9.87±0.12 to 13.4±0.23 weeks in the combination group, together with significant elevation of reduced glutathione(GSH), superoxide dismutase (SOD) catalase (CAT) and reduction in lipid peroxidation (LPO) was observed ascompared to the control group.