Relationship between Serum Levels of Superoxide Dismutase Activity and Subsequent Risk of Cancer Mortality: Findings from a Nested Case-control Study within the Japan Collaborative Cohort Study

Abstract

Superoxide dismutases (SODs) are antioxidant enzymes that play a role in the defense system of the body.They may be involved in protection against carcinogenesis processes. In the present study, we investigate theassociation between serum SOD activity and the risk of deaths due to all cancers combined, based on a nestedcase-control study within the Japan Collaborative Cohort Study of 914 cancer deaths and 2,739 matched controls.Blood samples were obtained at the baseline and stored at -80ºC until analysis for SOD levels. Serum levels ofSODs were divided into quartiles, with the first quartile used as the reference. A conditional logistic model wasused to estimate odds ratios (ORs) for total cancer mortality associated with serum SOD quartile levels. Theadjusted ORs and 95% confidence intervals (CIs) for the second, third and fourth SOD quartiles were 0.96(95%CI: 0.77-1.19), 1.18 (0.92-1.51), and 1.32 (1.04-1.69), respectively. In analyses stratified by observationperiod, the adjusted ORs of the respective quartiles were 0.81 (95%CI: 0.60-1.08), 0.98 (0.70-1.37), and 1.28(0.92-1.79) for the period from the baseline to 1994; and the adjusted ORs were 1.18 (95%CI: 0.85-1.63), 1.47(1.04-2.10), and 1.41 (1.00-2.04) for the period after 1994. To conclude, we found a slightly positive associationbetween serum SOD level and the risk of all cancer mortality in the present study. Elevated serum SOD levelsmight reflect a response to oxidative stress, and then may predict a state of excess reactive oxygen species in thecarcinogenesis process. Detailed studies of associations between serum SOD levels and cancers in specific sitesshould now be performed, with attention to particular tumour types.