Objective: Our aim was to investigation the roles of MHC class I chain-related gene A(MICA) and naturalkiller cell group 2D(NKG2D) in human renal cancer cells. Materials and Methods: The expression ...

Background: Carcinoma of the esophagus is associated with significant morbidity and mortality. The mostcommon subtype is squamous cell carcinoma (SCC). In the past three decades, the incidence of SCC has beenreported ...

Background: To verify whether serum tumor abnormal protein (TAP) would correlate with the responsivenessof palliative chemotherapy in patients with advanced gastric cancer, and the variation of conventional serumtumor ...

Background: Approaches in disruption of MDM2-p53 interactions have now emerged as an importanttherapeutic strategy in resurrecting wild type p53 functional status. The present study highlights virtual screeningstrategies ...

Cigarette smoke contains oxidants and free radicals which are carcinogens that can induce mutations inhumans. Single nucleotide polymorphisms (SNPs) are the most frequent genetic alterations found in the humangenome. In ...

Aloe-emodin (1, 8-dihydroxy-3-hydroxyl-methylanthraquinone; AE) and emodin (1,3,8-trihydroxy-6-methylanthraquinone; EM) are anthraquinone derivatives that have been detected in some medical plants andshare similar anthraquinone ...

Background: To evaluate pathological features of head and neck squamous cell carcinoma (HNSCC) and tocompare these pathological features in patients younger and older than 40 years. Materials and Methods: ...

Background: : Cervical cancer is the second most common cause of cancer related death of women. PersistentHPV infection, especially with high-risk types such as HPV16 and HPV18, has been identified to be the ...

Context: Insulin-like growth factor peptides play important roles in regulating cell growth, cell differentiation,and apoptosis, and have been demonstrated to promote the development of colorectal cancer (CRC). ...

Objective: To investigate the effect of coenzyme complex on decreasing cardiotoxicity in elderly patients withgastrointestinal cancer who were treated by chemotherapy. Methods: From September 2011 ...

Oral, cervical and breast cancers, which are either preventable and/or amenable to early detection andtreatment, are the leading causes of cancer-related morbidity and mortality in India. In this paper, we describeimplementation ...

Background: Although cervical cancer is preventable and early screening might decrease the associatedmortality, challenges faced by the women and health care providers can postpone early detection. This qualitativestudy ...

Several improvements in ovarian cancer treatment have been achieved in recent years, both in surgeryand in combination chemotherapy with targeting. However, ovarian tumors remain the women’s cancers withhighest mortality ...

The purpose of this study is to assess the effect of consanguinity on breast cancer incidence in Tunisia. Weconducted a case-control study to evaluate the involvement of heterozygote and homozygote haplotypes ofBRCA1 gene ...

Background: Systemic inflammatory response was shown to play an important role in development andprogression of many cancer types and different inflammation-based indices were used for determining prognosis.We aimed ...

Background: Cholangiocarcinoma (CCA), or bile duct cancer, is incurable with a high mortality rate dueto a lack of effective early diagnosis and treatment. Identifying cytoplasmic membrane proteins of invasiveCCA ...

Background: Lung cancer is a fatal malignancy with high mortality and short survival time. The aim of thisstudy was to estimate survival rates of Iranian patients with lung cancer and its associate predictive ...

The p53 tumor suppressor protein is a principal mediator of growth arrest, senescence, and apoptosis inresponse to a broad array of cellular damage. p53 is a substrate for the ubiquitin-proteasome system, however,the ...

Background: A moderate dose of radiation is the recommended treatment for solitary plasmacytoma (SP),but there is controversy over the role of surgery. Our study aimed at comparing different treatment modalities ...

Objective: To evaluate the efficacy of mannatide combined with sodium cantharidate vitamin B6 in thetreatment of malignant pleural effusions. Materials and Methods: Data for 69 patients with malignant ...