Background: Retinoblastoma protein-interacting zinc finger gene 1(RIZ1) functions as a tumor suppressor.Hypermethylation-mediated RIZ1 silencing has been reported in several cancers, but not in renal cell carcinoma(RCC) ...

Background: Cholangiocarcinoma (CCA), or bile duct cancer, is incurable with a high mortality rate dueto a lack of effective early diagnosis and treatment. Identifying cytoplasmic membrane proteins of invasiveCCA ...

Leukemia is a clonal disorder with blocked normal differentiation and cell death of hematopoietic progenitorcells. Traditional modalities with most used radiation and chemotherapy are nonspecific and toxic which causeadverse ...

Purpose: To investigate the antitumor activity and mechanism of chloroquine (CQ) in combination withcisplatin (DDP) in nude mice xenografted with gastric cancer SGC7901 cells. Materials and Methods: 35 casesof ...

Arsenic trioxide (ATO) has been found to exert anti-cancer activity in various human malignancies. However,the molecular mechanisms by which ATO inhibits tumorigenesis are not fully elucidated. In the current study,we ...

Background: Systemic inflammatory response was shown to play an important role in development andprogression of many cancer types and different inflammation-based indices were used for determining prognosis.We aimed ...

Fatty liver disease (FLD) can be a precondition for other liver pathology including cholangiocarcinoma(CCA). Diabetes mellitus (DM) has been suggested in some studies to be a risk factor for FLD as well as cancers,including ...

Background: Men and women who smoke tend to show less compliance to screening guidelines than nonsmokers.However, a recent study in Korea showed that self-reported female smokers constituted less than halfof ...

To observe and analyze the characteristic trend of cancer patients hospitalized for the first time in ShanxiTumor Hospital from 2001 to 2010, clinical data including case number, age, gender, and frequency of differenttumor ...

The CCAAT/enhancer-binding protein-alpha (CEBPA) is a transcriptional factor that plays a crucial rolein the control of proliferation and differentiation of myeloid precursors. This gene was recognized as the targetof ...

Objective: To explore the clinical application of recombinant human endostatin (Endostar) in the treatmentof patients with non-small cell lung cancer (NSCLC) in Chinese mainland. Materials and Methods: ...

Background: To verify whether serum tumor abnormal protein (TAP) would correlate with the responsivenessof palliative chemotherapy in patients with advanced gastric cancer, and the variation of conventional serumtumor ...

Objective: To explore the clinical efficacy and toxic and side effects of recombinant human endostatin (rhendostatin/endostar) combined with chemotherapy in the treatment of advanced gastric cancer. Materials ...

Objective: To investigate the effect of coenzyme complex on decreasing cardiotoxicity in elderly patients withgastrointestinal cancer who were treated by chemotherapy. Methods: From September 2011 ...

Background: Cancer loci comprise heterogeneous cell populations with diverse cellular secretions. Therefore,disseminating cancer-specific or cancer-associated protein antigens from tissue lysates could only be ...

The purpose of this study is to assess the effect of consanguinity on breast cancer incidence in Tunisia. Weconducted a case-control study to evaluate the involvement of heterozygote and homozygote haplotypes ofBRCA1 gene ...

Background: Recent studies revealed a relationship between ground-glass opacity (GGO) ratio on computedtomography (CT) and serum carcinoembryonic antigen (CEA) level in lung adenocarcinoma. Since an associationbetween ...

Curcumin, a lipid-soluble compound extracted from the plant Curcuma Longa, has been found to exertimmunomodulatory effects via macrophages. However, most studies focus on the low bioavailability issue ofcurcumin by nano ...

Background: Colorectal cancer is one of the most commonly occurring cancers in China. Dietary fibre hasbeen thought to decrease the risk of colorectal cancer in Western countries. However, studies investigatingthe ...

Aloe-emodin (1, 8-dihydroxy-3-hydroxyl-methylanthraquinone; AE) and emodin (1,3,8-trihydroxy-6-methylanthraquinone; EM) are anthraquinone derivatives that have been detected in some medical plants andshare similar anthraquinone ...