Despite the extensive application of methotrexate (MTX) as a chemotherapeutic agent and an immune system suppressor, its therapeutic implementation has been limited due to its poor pharmacokinetics, saturable cellular ...

Management of ocular disease can be improved by prolonging the contact time of ophthalmic antibiotics with the ocular surface using bioadhesive polymers such as chitosan. Additionally, ...

The plants with high amounts of polyphenolic constituents may act as antioxidants or as producer of other mechanisms causing to anticarcinogenic or cardioprotective actions. So, the objective of the present survey is ...

Introduction: methotrexate (MTX) is a routinely used antifolate for the treatment of solid tumors and hematologic malignancies. However, high-dose MTX can lead to severe side effects and the patients are required to receive ...

Cirrhosis-associated muscle mass loss or sarcopenia is a common complication (17-30% prevalence) in cirrhotic patients. However, the pathogenesis of this complication is poorly understood. Therefore, finding the mechanisms ...

Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide and are usually multifactorial medical conditions. Usually cardiovascular patients must follow a complicated treatment scheme, containing several ...