Trends in Pharmaceutical Sciences
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Synthesis of some novel α-substituted phosphonic acids by Nano-SnCl4/SiO2 as antimicrobial agents
(Shiraz University of Medical Sciences, 2025-12-01)α-Substituted phosphonic acids exhibit promising antifungal activity by targeting key fungal metabolic pathways. Their structural versatility allows for enhanced binding affinity to fungal enzymes, inhibiting growth and ...
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Role of Antioxidant and Anti-inflammatory Parameters in the Renoprotective Effects of Valsartan against Renal Ischemia-Reperfusion Injury in Male Rats
(Shiraz University of Medical Sciences, 2025-12-01)ABSTRACTRenal ischemia-reperfusion (I/R) injury, causing acute kidney failure, involves inflammation, oxidative stress, and dysfunction. Valsartan, an angiotensin II receptor blocker, lowers blood pressure and has ...
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Highly Efficient Synthesis of Vasorelaxant Quinazolinone Derivatives under Ultrasonic Irradiation in the Presence of TiO2 Nanoparticles
(Shiraz University of Medical Sciences, 2025-12-01)Quinazolinone compounds are interesting pharmacophores with a wide range of biological activities. Among the most valuable quinazolinones are the 3-substituted 2-methylquinazolin-4(3H)-one derivatives. There are some reports ...
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A Comparative Analysis of Black Bile in Ancient Medicine and Oxidative Stress in Modern Science: Insights into Chronic Disease and Dietary Interventions
(Shiraz University of Medical Sciences, 2025-12-01)Black bile (Sauda) as one of the four humors from Persian medicine has links with melancholic temperament, gut issues, aging process, and also some cancer-related conditions. Some recent studies have discovered similarities ...
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The Evolution of AI and Its Transformative Role in Pharmaceutical Nanotechnology
(Shiraz University of Medical Sciences, 2025-12-01)Artificial intelligence (AI) is transforming pharmaceutical nanotechnology by enabling rapid, intelligent, and precise solutions to challenges in drug delivery, diagnosis, and material design. By using machine learning ...
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A pharmaceutical perspective on the potential of monkeypox outbreak to tackle future pandemics
(Shiraz University of Medical Sciences, 2025-12-01)Pandemics have devastating effects on human societies, leading to wreak havoc on economies and disrupting global education and health systems, slowing down sustainable development. Nevertheless, they may provide an opportunity ...
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Investigation of the Therapeutic, Physicochemical, and Pharmaceutical Properties of Bioactive Compounds from Citrullus colocynthis
(Shiraz University of Medical Sciences, 2025-09-01)Citrullus colocynthis is a perennial plant found in arid regions with medicinal properties. Its fruits contain bioactive compounds that offer laxative, anti-diabetic, and anti-cancer effects. However, there are toxicity ...
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Efficacy and Safety of Amlodipine with Torsemide in CKD with Hypertension in a Tertiary Care Hospital: A Prospective Observational Study
(Shiraz University of Medical Sciences, 2025-09-01)Managing hypertension in chronic kidney disease (CKD) patients remains challenging, especially in resource-constrained settings like India where comorbidities are prevalent. Combining amlodipine, a calcium channel blocker, ...
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Ivermectin inhibits acute chloroquine-induced scratching behavior by targeting p-NF-kB p65 and iNOS in mice
(Shiraz University of Medical Sciences, 2025-09-01)Pruritus, or itching, is one of the most common skin complaints. The intensity of the itching is sometimes so uncomfortable and irritating that the patient injures himself by repeatedly scratching. Skin damage, inflammation ...
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Antioxidant, Acetyl- and Butyrylcholinesterase Inhibitory Activities of a Memory Enhancer Formulation from Traditional Persian Medicine (TPM)
(Shiraz University of Medical Sciences, 2025-09-01)Alzheimer's (AD) is the most common type of dementia in humans. The cholinergic hypothesis is one of the most important theories behind the pathogenesis of AD. It claims that excessive activity of the enzyme acetylcholinesterase ...
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Synergistic therapeutic effect of the volatile oils of Zingiber officinale and Curcuma longa on Selected Advantageous Pathogens
(Shiraz University of Medical Sciences, 2025-09-01)In response to the escalating global drug resistance crisis, this study explores the potential of ginger (Zingiber officinale) and turmeric (Curcuma longa) volatile oils as alternative therapeutic agents individually and ...
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A review and viewpoints on the application of DNA barcoding for the authentication of dairy products and the identification of contaminants
(Shiraz University of Medical Sciences, 2025-09-01)Food adulteration, particularly in dairy products, poses significant economic and public health challenges worldwide. Milk and dairy products, valued for their nutritional content, are frequently targeted for fraudulent ...
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Application of electrophoresis in antiretroviral drug analysis: A comprehensive review
(Shiraz University of Medical Sciences, 2025-09-01)Human immunodeficiency virus (HIV) infection continues to pose a substantial global public health challenge, with recent data estimating that around 39 million people are currently living with the virus worldwide. While ...
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Multi-ingredient herbal topical preparations for the management of pain in osteoarthritis: A perspective from Persian Medicine
(Shiraz University of Medical Sciences, 2025-09-01)Osteoarthritis is one of the most common diseases worldwide today. Inflammation and pain caused by osteoarthritis greatly interfere with daily activities for those affected. Although many painkillers and medications are ...
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Molecular Identification and Phylogenetic Differentiation of Iranian Hypericum Species Using 18S rRNA Gene Barcoding and Bioinformatic Analysis
(Shiraz University of Medical Sciences, 2025-06-01)The Hypericum genus is renowned for its medicinal properties, yet its commercial products are often adulterated due to challenges in morphological identification. This study presents a molecular approach using 18S rRNA ...
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Design, Synthesis, Molecular Docking of Novel Quinazolinone-azole Derivatives as Anticancer A gents
(Shiraz University of Medical Sciences, 2025-06-01)Cancer encompasses a diverse group of diseases characterized by uncontrolled cell division, leading to immune system impairment and the potential to metastasize to other regions of the body. Globally, cancer represents a ...
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A Glimpse into the Pathophysiology, Classification, Clinical Presentations, and Management of Psoriasis
(Shiraz University of Medical Sciences, 2025-06-01)The skin and dermatological diseases have a considerable potential to impact a person's social conduct, self-esteem, and willingness to engage in social interactions. The burden of skin diseases includes both their high ...
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Drug Utilization Evaluation (DUE) of Captopril in Two Coronary Care Units (CCU) of Namazi Hospital, Shiraz, Iran
(Shiraz University of Medical Sciences, 2025-06-01)Background: Captopril is one of the most important medicines prescribed for managing cardiovascular disorders. Therefore, its appropriate prescription, dosage, and other drug-related factors of captopril have indispensable ...
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Graphene Nanostructures: Pioneering Drug Delivery Vehicles for Targeting Etoposide to Cancer Cells
(Shiraz University of Medical Sciences, 2025-06-01)Etoposide (ETO) is a formidable chemotherapeutic agent that holds great promise for individuals grappling with various forms of cancer, including testicular, prostate, bladder, stomach, and lung malignancies. While traditional ...
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Atorvastatin loaded PVA/alginate fibers as a potential wound dressing
(Shiraz University of Medical Sciences, 2025-06-01)Wound healing is a complex process that involves cellular and biochemical aspects. Many effective methods and formulations for wound healing have been reported in the studies. Hydrogels containing biodegradable and ...
