Volume 25, Issue 5
مرور بر اساس
ارسال های اخیر
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Effects of CYP2C19 variants on the metabolism of tapentadol <i>in vitro</i>
(Mashhad University of Medical Sciences, 2022-05-01)Objective(s): This study aims to evaluate the catalytic activities of 31 CYP2C19 alleles and their effects on the metabolism of tapentadol in vitro. Materials and Methods: Insect microsomes expressing the CYP2C19 alleles ...
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Acute lung injury induced by acute uremia and renal ischemic-reperfusion injury: The role of toll-like receptors 2 and 4, and oxidative stress
(Mashhad University of Medical Sciences, 2022-05-01)Objective(s): Acute lung injury (ALI) is a common complication of distant organ dysfunction induced by acute kidney injury (AKI). Toll-like receptors (TLRs) have a critical role in progression of AKI. The main goal of this ...
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6-O-angeloylplenolin inhibits anti-IgE-stimulated human mast cell activation via suppressing calcium influx and ERK phosphorylation
(Mashhad University of Medical Sciences, 2022-05-01)Objective(s): Mast cells are important immune cells that primarily localize in the interface between the host and external environment, and protect us from pathogen infection. However, they are also involved in the pathology ...
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Transient receptor potential vanilloid type-1 regulates periodontal disease damage via the PI3K/AKT signaling pathway
(Mashhad University of Medical Sciences, 2022-05-01)Objective(s): This study aimed to investigate the function of transient receptor potential vanilloid 1 (TRPV1) in regulating periodontal lesions. In addition, we explored the underlying mechanism of the phosphatidylinositol ...
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Synaptic plasticity and cognitive impairment consequences to acute kidney injury: Protective role of ellagic acid
(Mashhad University of Medical Sciences, 2022-05-01)Objective(s): The goal of the current experiment was to define the efficacy and underlying molecular mechanisms of Ellagic acid (EA) on acute kidney injury (AKI) induced impairment in cognitive and synaptic plasticity in ...
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Effect of electrical stimulation of central nucleus of the amygdala on morphine conditioned place preference in male rats
(Mashhad University of Medical Sciences, 2022-05-01)Objective(s): The central nucleus of the amygdala (CeA) is one of the most important areas for the morphine reward system. This study investigated the effect of electrical stimulation of CeA on morphine conditioned place ...
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TAX and HBZ: hFc Ɣ 1 proteins as targets for passive immunotherapy
(Mashhad University of Medical Sciences, 2022-05-01)Objective(s): Human T leukemia virus type one (HTLV-1) causes two life-threatening diseases in around five percent of infected subjects, a T cell malignancy and a neurodegenerative disease. TAX and HBZ are the main virulence ...
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Anti-PCSK9 monoclonal antibody attenuates high-fat diet and zymosan-induced vascular inflammation in C57BL/6 mice by modulating TLR2/NF-ƙB signaling pathway
(Mashhad University of Medical Sciences, 2022-05-01)Objective(s): Excess intake of a high-fatty diet (HFD) together with zymosan administration mediates vasculitis response which leads to impaired serum lipid levels and causes arterial stiffness. In the development of new ...
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Effect of MK-801, an antagonist of NMDA receptor in the pedunculopontine tegmental nucleus, on cardiovascular parameters in normotensive and hydralazine hypotensive rats
(Mashhad University of Medical Sciences, 2022-05-01)Objective(s): In the present study, the cardiovascular effects of glutamate NMDA receptor of the pedunculopontine tegmental nucleus (PPT) in normotensive and hydralazine (HLZ) hypotensive rats were evaluated. Materials and ...
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Effects of citicoline administration on synaptic proteins in rapid eye movement sleep-deprived rats
(Mashhad University of Medical Sciences, 2022-05-01)Objective(s): Sleep has a pivotal role in learning-memory and sleep deprivation (SD) negatively affects synaptic functioning. Cytidine-5-diphosphocholine (Citicoline) has been known to improve learning and memory functions. ...
