Volume 24, Issue 10
مرور بر اساس
ارسال های اخیر
-
Huperzine A protects against traumatic brain injury through anti-oxidative effects via the Nrf2-ARE pathway
(Mashhad University of Medical Sciences, 2021-10-01)Objective(s): Traumatic brain injury (TBI) is a prominent health problem worldwide and it may lead to cognitive dysfunction, disability, and even death. To date, there is no effective treatment for TBI. Our previous study ...
-
Effects of synthetic silymarin-PLGA nanoparticles on M2 polarization and inflammatory cytokines in LPS-treated murine peritoneal macrophages
(Mashhad University of Medical Sciences, 2021-10-01)Objective(s): Silymarin (SM) is a natural antioxidant compound with good anti-inflammatory effects, but its poor water solubility restricts its usage. Today, nanomaterial compounds (such as PLGA Poly D, L-lactic-co-glycolic ...
-
Inhibition of aluminum chloride-induced amyloid Aβ peptide accumulation and brain neurodegeneration by <i>Bougainvillea spectabilis</i> flower decoction
(Mashhad University of Medical Sciences, 2021-10-01)Objective(s): To investigate the potential therapeutic effect of Bougainvillea spectabilis flower decoction on aluminum chloride (AlCl3)-induced neurotoxicity. Materials and Methods: Rats received daily intraperitoneal ...
-
Dimethylaminoparthenolide (DMAPT) as an alternative approach for treatment of Familial Mediterranean Fever (FMF)
(Mashhad University of Medical Sciences, 2021-10-01)Objective(s): Familial Mediterranean Fever (FMF) is a hereditary auto-inflammatory disorder that is caused by mutations in the Mediterranean fever (MEFV) gene and is associated with an increase in pro-inflammatory cytokines, ...
-
The impact of moderate-intensity swimming exercise on learning and memory in aged rats: The role of Sirtuin-1
(Mashhad University of Medical Sciences, 2021-10-01)Objective(s): The purpose of this study was to evaluate the effect of moderate-intensity swimming exercise on learning and memory by the Morris water maze test. Changes in the expressions of cyclic AMP-response element-binding ...
-
Evaluation of debridement effects of bromelain-loaded sodium alginate nanoparticles incorporated into chitosan hydrogel in animal models
(Mashhad University of Medical Sciences, 2021-10-01)Objective(s): Bromelain, a mixture of proteolytic enzymes from pineapple (Ananas comosus) is known as a potential debriding agent in burn treatment. In this research, the debridement efficiency of chitosan hydrogel loaded ...
-
Atorvastatin modulates the expression of aging-related genes in the brain of aging induced by D-galactose in mice
(Mashhad University of Medical Sciences, 2021-10-01)Objective(s): Atorvastatin (AT), a competitive inhibitor of 3-hydroxymethyl-3-glutaryl-coenzyme-A reductase, is a cholesterol-lowering drug. AT has been shown to have neuroprotective, antioxidant, and anti-inflammatory ...
-
A2 adenosine receptor contributes to the development of cow’s milk protein allergy via regulating regulatory T cells
(Mashhad University of Medical Sciences, 2021-10-01)Objective(s): A2 adenosine receptor (A2AR) is a novel promising target for the treatment of inflammatory and allergic diseases. However, its role in the development of cow's milk protein allergy (CMPA) has not been elucidated. ...
-
Preparation and evaluation of the exotoxin A nano-gold conjugate as a vaccine candidate for <i>Pseudomonas aeruginosa</i> infections
(Mashhad University of Medical Sciences, 2021-10-01)Objective(s): Pseudomonas aeruginosa is an opportunistic pathogen that is an important cause of nosocomial infections. This bacterium produces various virulence factors, among which exotoxin A is significantly involved in ...
-
Liraglutide ameliorates myocardial damage in experimental diabetic rats by inhibiting pyroptosis via Sirt1/AMPK signaling
(Mashhad University of Medical Sciences, 2021-10-01)Objective(s): Liraglutide, a well-established drug for treating diabetes mellitus (DM), has recently gained attention for its cardiovascular benefits in diabetes via multiple cellular activities; however, whether liraglutide ...
-
Description of the calf thymus DNA-malathion complex behavior by multi-spectroscopic and molecular modeling techniques: EMF at low and high frequency approaches
(Mashhad University of Medical Sciences, 2021-10-01)Objective(s): Small molecules can bind to DNA via covalent or non-covalent interactions, which results in altering or inhibiting the function of DNA. Thus, understanding the interaction patterns of medicines or other small ...
-
Game theory applications in host-microbe interactions toward disease manifestation: <i>Mycobacterium tuberculosis</i> infection as an example
(Mashhad University of Medical Sciences, 2021-10-01)Objective(s): Game theory describes the interactions between two players and the pay-off from winning, losing, or compromising. In the present study, Mycobacterium tuberculosis (Mtb)–host interactions were used as an example ...
