Volume 24, Issue 12
مرور بر اساس
ارسال های اخیر
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Combined effect of hydrogen sulfide and mesenchymal stem cells on mitigating liver fibrosis induced by bile duct ligation: Role of anti-inflammatory, anti-oxidant, anti-apoptotic, and anti-fibrotic biomarkers
(Mashhad University of Medical Sciences, 2021-12-01)Objective(s): Liver fibrosis eventually develops into cirrhosis and hepatic failure, which can only be treated with liver transplantation. We aimed to assess the potential role of hydrogen sulfide (H2S) alone and combined ...
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G-CSF augments the neuroprotective effect of conditioned medium of dental pulp stem cells against hypoxic neural injury in SH-SY5Y cells
(Mashhad University of Medical Sciences, 2021-12-01)Objective(s): Dental pulp stem cells (DPSCs) can differentiate into functional neurons and have the potential for cell therapy in neurological diseases. Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein family ...
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Curcumin protects human umbilical vein endothelial cells against high oxidized low density lipoprotein-induced lipotoxicity and modulates autophagy
(Mashhad University of Medical Sciences, 2021-12-01)Objective(s): Endothelial dysfunction is a precursor of cardiovascular disease, and protecting endothelial cells from damage is a treatment strategy for atherosclerosis (AS). Curcumin, a natural polyphenolic compound, has ...
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Vitexin ameliorates GCDC-induced hepatocyte injury through SIRT6 and JAK2/STAT3 pathways
(Mashhad University of Medical Sciences, 2021-12-01)Objective(s): Vitexin, a natural flavonoid, is commonly found in many foods and traditional herbal medicines and has clear health benefits. However, the role of vitexin in cholestasis is presently unclear. This study ...
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Effects of prolactin on movement disorders and APOE, GFAP, and PRL receptor gene expression following intracerebral hemorrhage in rats
(Mashhad University of Medical Sciences, 2021-12-01)Objective(s): Intracerebral hemorrhage (ICH) occurs mostly in the striatum. In ICH, blood prolactin level increases 3-fold. The effects of intracerebroventricular injection (ICV) of prolactin on motor disorders will be ...
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Different microRNAs contribute to the protective effect of mesenchymal stem cell-derived microvesicles in LPS induced acute respiratory distress syndrome
(Mashhad University of Medical Sciences, 2021-12-01)Objective(s): The present study aimed to determine whether bone marrow mesenchymal stem cell-derived microvesicles (MSC MVs) were effective in restoring lung tissue structure, and to assess the potential role of miRNAs in ...
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Design and physico-mechanical evaluation of fast-dissolving valsartan polymeric drug delivery system by electrospinning method
(Mashhad University of Medical Sciences, 2021-12-01)Objective(s): Chronic hypertension is a pervasive morbidity and the leading risk factor for cardiovascular diseases. Valsartan, as an antihypertensive drug, has low solubility and bioavailability. The application of ...
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Ischemic post-conditioning is neuroprotective even at delayed tPA administration after embolic stroke in female rats
(Mashhad University of Medical Sciences, 2021-12-01)Objective(s): Delayed tissue plasminogen activator (tPA) thrombolysis is accompanied by different complications in stroke patients. Studies reported sex differences in stroke therapy. Ischemic postconditioning (PC) unveils ...
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Effect of transgenic <i>Leishmania major</i> expressing <i>mLLO-Bax-Smac</i> fusion gene in the apoptosis of the infected macrophages
(Mashhad University of Medical Sciences, 2021-12-01)Objective(s): Leishmaniasis is a complex infection against which no confirmed vaccine has been reported so far. Transgenic expression of proteins involved in macrophage apoptosis-like BAX through the parasite itself ...
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Corilagin potential in inhibiting oxidative and inflammatory stress in LPS-induced murine macrophage cell lines (RAW 264.7)
(Mashhad University of Medical Sciences, 2021-12-01)Objective(s): Inflammation is thought to be the common pathophysiological basis for several disorders. Corilagin is one of the major active compounds which showed broad-spectrum biological and therapeutic activities, such ...
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Development and immunohistochemical characterization of patient-derived xenograft models for muscle invasive bladder cancer
(Mashhad University of Medical Sciences, 2021-12-01)Objective(s): Patient-derived xenograft (PDX) models have become a valuable tool to evaluate chemotherapeutics and investigate personalized cancer treatment options. The role of PDXs in the study of bladder cancer, especially ...
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Novel oxadiazole derivatives as potent inhibitors of α-amylase and α-glucosidase enzymes: Synthesis, <i>in vitro</i> evaluation, and molecular docking studies
(Mashhad University of Medical Sciences, 2021-12-01)Objective(s): Alpha-amylase and alpha-glucosidase enzyme inhibition is an effective and rational approach for controlling postprandial hyperglycemia in type II diabetes mellitus (DM). Several inhibitors of this therapeutic ...
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Voluntary exercise could reduce sperm malformations by improving hypothalamus-hypophysis-gonadal axis and kisspeptin/leptin signaling in type 2 diabetic rats
(Mashhad University of Medical Sciences, 2021-12-01)Objective(s): Most male patients with type 2 diabetes mellitus (T2DM) experience infertility. It is well established that regular physical activity could alleviate diabetic infertility symptoms. This study was designed to ...
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Anti-inflammatory, anti-oxidant, and immunomodulatory activities of the genus <i>Ferula</i> and their constituents: A review
(Mashhad University of Medical Sciences, 2021-12-01)Objective(s): Ferula is a genus of the family Apiaceae and it includes around 170 species of flowering plants mostly native to the Mediterranean region and eastern to central Asia. In Iran, Ferula spp. are widely used in ...
