Volume 24, Issue 9
مرور بر اساس
ارسال های اخیر
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Differential expressions of miR-223, miR-424, miR-145, miR-200c, miR-139 in experimental rat chronic pancreatitis model and their relationship between oxidative stress, endoplasmic reticulum stress, and apoptosis
(Mashhad University of Medical Sciences, 2021-09-01)Objective(s): This study aimed to research the roles of miR-139, miR-221, miR-200c, miR-145, miR-223, miR-424, and miR-377 in endoplasmic reticulum stress (ERS), oxidative stress (OS), fibrosis, and apoptosis processes in ...
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Suppressive effects of dental pulp stem cells and its conditioned medium on development and migration of colorectal cancer cells through MAPKinase pathways
(Mashhad University of Medical Sciences, 2021-09-01)Objective(s): Mesenchymal stem cells (MSCs) extensively interact with cancer cells and other stromal cells in the tumor microenvironment. However, the role of MSCs in colorectal cancer (CRC) development and metastasis is ...
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Propranolol-loaded electrospun nanofibrous wound dressing: From fabrication and characterization to preliminary wound healing evaluation
(Mashhad University of Medical Sciences, 2021-09-01)Objective(s): The wound healing potential of beta-blocker drugs such as propranolol (PNL) has recently attracted attention. To date, incorporation of PNL into electrospun nanofibrous wound dressing mats has not been tested ...
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GABAergic neurons in the nucleus accumbens regulate hedonic food intake via orexin-a expression in the lateral hypothalamus
(Mashhad University of Medical Sciences, 2021-09-01)Objective(s): To investigate the regulatory effects of the nucleus accumbens (NAcSh)-lateral hypothalamus (LHA) GABAergic neural pathway on palatable food (PF) intake via orexin-A expression in diet-induced obesity (DIO) ...
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Irisin protects female mice with LPS-induced endometritis through the AMPK/NF-κB pathway
(Mashhad University of Medical Sciences, 2021-09-01)Objective(s): This research was designed to determine the role of irisin in lipopolysaccharide (LPS)-induced endometritis in female mice. Materials and Methods: Animals were randomly assigned into sham, sham + irisin, LPS, ...
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Effect of using different co-ligands during 99mTc-labeling of J18 peptide on SK-MES-1 cell binding and tumor targeting
(Mashhad University of Medical Sciences, 2021-09-01)Objective(s): Lung cancer is the main cause of cancer death, and its incidence is increasing worldwide. The goal of this study is to evaluate in vitro and in vivo tumor targeting behavior of [99mTc]Tc -HYNIC-(Ser)3-J18 in ...
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Evaluation of <i>Helicobacter pylori</i> OipA protein as a vaccine candidate and propolis as an adjuvant in C57BL/6 mice
(Mashhad University of Medical Sciences, 2021-09-01)Objective(s): Outer inflammatory protein A (OipA) is an essential adhesin of Helicobacter pylori. We aimed to evaluate the effects of a recombinant OipA in the induction of crucial cytokines as a vaccine candidate and ...
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Synergistic anti-cancer effects of silibinin-etoposide combination against human breast carcinoma MCF-7 and MDA-MB-231 cell lines
(Mashhad University of Medical Sciences, 2021-09-01)Objective(s): Recently, there is a significant focus on combination chemotherapy for cancer using a cytotoxic drug and a phytochemical compound. We investigated the effect of silibinin on etoposide-induced apoptosis in ...
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PLA2G6 gene mutation and infantile neuroaxonal degeneration; report of three cases from Iran
(Mashhad University of Medical Sciences, 2021-09-01)Objective(s): Infantile neuroaxonal degeneration (INAD) is a rare subgroup of neurodegeneration with brain iron accumulation (NBIA) disorders. This progressive disorder may develop during the early years of life. Affected ...
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Protective effect of cannabinoids on gastric mucosal lesions induced by water immersion restrain stress in rats
(Mashhad University of Medical Sciences, 2021-09-01)Objective(s): This study aimed to determine the impact of cannabinoid agonists and antagonists on the mucosal lesion progress in the stomach induced by water-immersion restraint stress (WIRS). Materials and Methods: Rats ...
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Neuroprotective effects of Wharton’s jelly-derived mesenchymal stem cells on motor deficits due to Parkinson’s disease
(Mashhad University of Medical Sciences, 2021-09-01)Objective(s): Human Wharton's jelly-derived mesenchymal stem cells (hWJ-MSCs) have been recognized as a potential tool to replace damaged cells by improving the survival of the dopaminergic cells in Parkinson's disease ...
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Green tea and metabolic syndrome: A 10-year research update review
(Mashhad University of Medical Sciences, 2021-09-01)Metabolic syndrome (MetS) has turned into a prevalent condition that has imposed a tremendous financial strain on public health care systems. It is believed that the MetS consists of four main factors (hypertension, ...
