Volume 24, Issue 8
مرور بر اساس
ارسال های اخیر
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Dystrophin gene editing by CRISPR/Cas9 system in human skeletal muscle cell line (HSkMC)
(Mashhad University of Medical Sciences, 2021-08-01)Objective(s): Duchene muscular dystrophy (DMD) is a progressive neuromuscular disease caused by mutations in the DMD gene, resulting in the absence of dystrophin expression leading to membrane fragility and myofibril ...
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<i>Ginkgo biloba</i> leaf extract (EGb-761) elicits neuroprotection against cerebral ischemia/reperfusion injury by enhancement of autophagy flux in neurons in the penumbra
(Mashhad University of Medical Sciences, 2021-08-01)Objective(s): Ginkgo biloba leaf extract (EGb-761) injection has been widely used as adjuvant therapy for cerebral stroke in China. However, its underlying pharmacological mechanism is not completely understood. The present ...
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Prevalence of bacteriocin genes in <i>Lactobacillus</i> strains isolated from fecal samples of healthy individuals and their inhibitory effect against foodborne pathogens
(Mashhad University of Medical Sciences, 2021-08-01)Objective(s): Foodborne diseases are considered as an important public health issue. The purpose of the current study was to isolate Lactobacillus spp. strains from fecal samples, investigate their antimicrobial properties, ...
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Intranasal administration of immunogenic poly-epitope from <i>influenza</i> H1N1 and H3N2 viruses adjuvanted with chitin and chitosan microparticles in BALB/c mice
(Mashhad University of Medical Sciences, 2021-08-01)Objective(s): Prevalence of influenza virus, creates the need to achieve an efficient vaccine against it. We examined whether the predicted antigenic epitopes of HA, NP, and M2 proteins of the influenza H1N1 and H3N2 viruses ...
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Alpha-lipoic acid could attenuate the effect of chemerin-induced diabetic nephropathy progression
(Mashhad University of Medical Sciences, 2021-08-01)Objective(s): Chemerin is associated with insulin resistance, obesity, and metabolic syndrome. α-lipoic acid (α-LA) is a potent antioxidant involved in the reduction of diabetic symptoms. This study aimed to investigate ...
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Attenuation of tacrolimus induced oxidative stress, mitochondrial damage, and cell cycle arrest by <i>Boerhavia diffusa</i> root fraction in mdck cell lines
(Mashhad University of Medical Sciences, 2021-08-01)Objective(s): The protective effect of ethyl acetate fraction (EAF) of Boerhavia diffusa roots against Tacrolimus (TAC) induced nephrotoxicity was studied using MDCK cell lines.Materials and Methods: Ethanolic root extract ...
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Interaction of miR-146a-5p with oxidative stress and inflammation in complications of type 2 diabetes mellitus in male rats: antioxidant and anti-inflammatory protection strategies in type 2 diabetic retinopathy
(Mashhad University of Medical Sciences, 2021-08-01)Objective(s): This study aimed to evaluate the role of miR-146a-5p in the pathogenesis of diabetic retinopathy and its interaction with oxidative stress and inflammation in the ocular tissue of rats with type 2 diabetes ...
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Potential secondary metabolite from Indonesian Actinobacteria (InaCC A758) against <i>Mycobacterium tuberculosis</i>
(Mashhad University of Medical Sciences, 2021-08-01)Objective(s): This study explored Indonesian Actinobacteria which were isolated from Curcuma zedoaria endophytic microbes and mangrove ecosystem for new antimycobacterial compounds. Materials and Methods: Antimycobacterial ...
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Expression of SR-B1 receptor in breast cancer cell lines, MDA-MB-468 and MCF-7: Effect on cell proliferation and apoptosis
(Mashhad University of Medical Sciences, 2021-08-01)Objective(s): High-density lipoprotein (HDL) is necessary for proliferation of several cells. The growth of many kinds of cells, such as breast cancer cells (BCC) is motivated by HDL. Cellular uptake of cholesterol from ...
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Pretreatment with licochalcone a enhances therapeutic activity of rat bone marrow mesenchymal stem cells in animal models of colitis
(Mashhad University of Medical Sciences, 2021-08-01)Objective(s): Colitis has a high prevalence rate, limited treatment options, and needs to be solved urgently. Application of Licochacone A (LA) or rBMMSCs alone in the treatment of colitis has a certain but limited effect. ...
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Protective effects of selenium on acrylamide-induced neurotoxicity and hepatotoxicity in rats
(Mashhad University of Medical Sciences, 2021-08-01)Objective(s): Acrylamide (ACR), has wide uses in different industries. ACR induced several toxicities including neurotoxicity and hepatotoxicity. The probable protective effects of selenium on ACR-induced neurotoxicity and ...
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<i>MKK4</i> variants rs3826392 and rs3809728 are associated with susceptibility and clinicopathological features in colorectal cancer patients
(Mashhad University of Medical Sciences, 2021-08-01)Objective(s): The mitogen-activated protein kinase kinase 4 (MKK4) plays a key role in several processes like inflammation, apoptosis, and tumorigenesis. Several authors have proposed that genetic variations in these genes ...
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Thymoquinone against infectious diseases: Perspectives in recent pandemics and future therapeutics
(Mashhad University of Medical Sciences, 2021-08-01)The recent pandemics caused by coronavirus infections have become major challenges in 21st century human health. Scientists are struggling hard to develop a complete cure for infectious diseases, for example, drugs or ...
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Modulatory role of atorvastatin against high-fat diet and zymosan-induced activation of TLR2/NF-ƙB signaling pathway in C57BL/6 mice
(Mashhad University of Medical Sciences, 2021-08-01)Objective(s): Accumulated evidence provides a strong connection between the immune system and vascular inflammation. The innate immune system's main sensors are toll-like receptors (TLRs). Zymosan (Zym), a fungal product, ...
