Volume 24, Issue 7
مرور بر اساس
ارسال های اخیر
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Evaluation of Interleukin-32 and cyclooxygenase-2 expression in HAM/TSP patients and HTLV-1 asymptomatic carriers
(Mashhad University of Medical Sciences, 2021-07-01)Objective(s): HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neuroinflammatory disorder associated with HTLV-1. Cytokines and inflammatory mediators have a major role in forming inflammation in ...
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Knockout of PKC θ gene attenuates oleic acid-induced acute lung injury via reduction of inflammation and oxidative stress
(Mashhad University of Medical Sciences, 2021-07-01)Objective(s): Acute respiratory distress syndrome resulting from acute lung injury has become a momentous clinical concern because of high morbidity and mortality in discharged patients with pulmonary and nonpulmonary ...
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Adrenomedullin increases cAMP accumulation and BDNF expression in rat DRG and spinal motor neurons
(Mashhad University of Medical Sciences, 2021-07-01)Objective(s): Adrenomedullin (AM) has high expression in the spinal cord. In this study, we investigated the expression of AM and its receptor components, including calcitonin receptor-like receptor (CLR) and receptor ...
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Differential pathogenesis of intracerebral and intramuscular inoculation of street rabies virus and CVS-11 strains in a mouse model
(Mashhad University of Medical Sciences, 2021-07-01)Objective(s): The mechanisms of rabies evasion and immunological interactions with the host defense have not been completely elucidated. Here, we evaluated the dynamic changes in the number of astrocytes, microglial and ...
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Urapidil alleviates ovarian torsion detorsion injury via regulating oxidative stress, apoptosis, autophagia, and inflammation
(Mashhad University of Medical Sciences, 2021-07-01)Objective(s): This study aimed to determine anti-inflammatory, antioxidant, and antiapoptotic properties of urapidil (Ura) against ovarian torsion detorsion (T/D) injury in rats. Materials and Methods: 40 female Wistar ...
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Antimicrobial resistance patterns, virulence gene profiles, and genetic diversity of <i>Salmonella enterica</i> serotype Enteritidis isolated from patients with gastroenteritis in various Iranian cities
(Mashhad University of Medical Sciences, 2021-07-01)Objective(s): This study aimed to evaluate antibiotic resistance profiles and presence of virulence genes among Salmonella enterica serovar Enteritidis (S. Enteritidis) isolated from patients with gastroenteritis in various ...
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Anti-LINGO -1 improved remyelination and neurobehavioral deficit in cuprizone-induced demyelination
(Mashhad University of Medical Sciences, 2021-07-01)Objective(s): Central nervous system demyelination is the main feature of multiple sclerosis (MS). The most important unmet need in MS is use of treatments that delay the progression of the disease. Leucine-rich repeat ...
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Cardioprotective effects of co-administration of thymoquinone and ischemic postconditioning in diabetic rats
(Mashhad University of Medical Sciences, 2021-07-01)Objective(s): Ischemia/reperfusion (I/R) is a leading cause of myocardial infarction (MI) injury, contributing to excess injury to cardiac tissues involved in inflammation, apoptosis, and oxidative stress. The present study ...
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Thymoquinone improves cognitive and hippocampal long-term potentiation deficits due to hepatic encephalopathy in rats
(Mashhad University of Medical Sciences, 2021-07-01)Objective(s): Hepatic encephalopathy (HE) is a neuropsychiatric syndrome that causes brain disturbances. Thymoquinone (TQ) has a wide spectrum of activities such as antioxidant, anti-inflammatory, and anticancer. This study ...
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In search of elixir: Pharmacological agents against stem cell senescence
(Mashhad University of Medical Sciences, 2021-07-01)Stem cell senescence causes different complications. In addition to the aging phenomenon, stem cell senescence has been investigated in various concepts such as cancer, adverse drug effects, and as a limiting factor in ...
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Effects of illicit drugs on structural and functional impairment of testis, endocrinal disorders, and molecular alterations of the semen
(Mashhad University of Medical Sciences, 2021-07-01)Illicit drug use is growing among young people, which is one of the major problems in today's society that can be associated with many medical issues, including infertility. Amphetamines, cocaine, opioids, and marijuana ...
