Effects of Cinnamon Extract on Curing and Preventing Gentamicin-induced Nephrotoxicity in Immature White Rats

Abstract

Background and purpose: Gentamicin-induced nephrotoxicity results from the production of reactive oxygen species (ROS) in the kidneys, and since cinnamon has antioxidant properties, this research studied the effects of cinnamon extract on the prevention and treatment of gentamicin-induced toxicity in immature white rats.Materials and methodology: in this study 36 immature female Wistar rats were divided into 6 equal groups. The control group did not receive any solution or medication. Every day The control group 1 received 200mg/kg hydro-alcoholic extract of cinnamon in Gavage form, the control group 2 received 80 mg/kg Gentimicin in intraperitoneal injection form, and empirical groups 1, 2 and 3 received 80 mg/kg Gentimicin in intraperitoneal injection form and 50, 100 and 200 mg Hydro-alcoholic extract of cinnamon in Gavage form for 14 days, respectively. Findings: Results show that serum concentrations of uric acid in sham group II increased significantly compared to the control group at 5%, and that the concentrations of urea and creatinine in sham group II and in the experimental group I were significantly higher compared to the control group at 1%. The diameter of proximal tubules in sham group II was significantly larger compared to the other groups (p<0.05). Furthermore, the diameter of glomeruli in the experimental groups and in sham group II significantly increased compared to the control group and sham group I. Conclusions: Cinnamon extracts have antioxidant properties and somewhat reduce the negative effects of Gentamicin. Therefore, it is recommended cinnamon extracts be used to reduce Gentamicin-induced nephrotoxicity in patients