Antibacterial Activity of Mesoporous Silica Nanofibers

Abstract

<em>In this research, </em><em>the </em><em>fabrication of MCM-41 mesoporous material nanofibers by an electrospinning technique was performed. </em><em>The MCM-41 nanofibers (MCM-41 NFs) as a novel host</em><em> on the </em><em>incorporation of silver has been studied in [Ag(NH₃)₂]NO₃ precursor solution through the heat-treatment process. The formation of silver-loaded MCM-41 NFs at various calcinating temperatures were also studied. The silver-containing materials (Ag/MCM-41 NFs) were characterized using Fourier Transform InfraRed (FT-IR) spectroscopy, powder X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), </em><em>UltraViolet-Visible Diffuse Reflectance Spectroscopy (UV-Vis DRS)</em><em>,</em><em> and Transmission Electron Microscopy (TEM). The results indicated that both Ag and Ag₂O NanoParticles (NPs) were loaded in MCM-41 NFs at different calcinating temperature. Silver compounds with a diameter of 10−15 nm were highly dispersed in the framework of mesoporous silica nanofibers. The results indicated that Ag loading contents on the MCM-41NFs were 10.53 wt%. These Ag/MCM-41 NFs Possess an enhanced antibacterial effective against both Gram-positive and Gram-negative bacteria by preventing the aggregation of silver NPs and continuously releasing silver ions. </em><em>In general, the silver-containing materials with more Ag₂O NPs demonstrated an excellent antibacterial activity. </em><em>The Minimum Inhibitory Concentrations (MIC) obtained 30 and 60 µg/mL</em><em>for </em><em>the silver-containing MCM-41 NFs with more Ag₂O NPs</em><em> against </em><em>E. coli and S. aureus</em><em>,</em><em> respectively</em><em>. MCM-41 type nanofibers play an important role in the antibacterial activity of nanocomposites.</em>