Synthesis, Reactions and Antioxidant Activity of 5-(3', 4'-dihydroxy-tetrahydrofuran-2'-yl)-2-methyl-3-carbohydrazide

Abstract

<em>In this manuscript, we describe the synthesis of the carbohydrazide 2.</em><em> Acid-catalyzed condensation with several carbonyl compounds to afford the corresponding carbohydrazide derivatives 3-12. Their acetylation afforded the corresponding acetyl derivatives 13-22.</em><em> Oxidative cyclization of O-acetyl derivatives 19-22 afforded the corresponding 1,3,4-oxadiazole derivatives 23-26</em><em>. </em><em>On the other hand, condensation</em><em> of </em><em>the dicarbonyl compound 27 with several aroylhydrazines to give the corresponding bisaroylhydrazones 28-32 cyclization of 28-31 afforded 1,3,4-oxadiazoles 33-36. The structures of the prepared compounds were confirmed by </em><em>¹</em><em>HNMR</em> <em>and Mass Spectra. The mechanism of the formation of the products was discussed. Furthermore,</em><em> the antioxidant activities of some of the prepared compounds were</em><em> examined.</em>