Chemical Composition and Biological Activities of Essential Oil and Methanol Extract of Teucrium scordium

Abstract

<em>In this study, the chemical composition of the essential oil of <em>Teucrium scordium</em> was studied using capillary GC and GC/MS instruments. In addition, the antimicrobial and cytotoxic activities of the oil and methanol extract were evaluated by disc diffusion and MTT assays, respectively. Forty-three volatile components were identified from the oil of aerial parts, representing of 98.1% of total oil. The major constituents were trans-α-bergamotene (52.3%), </em><em>(Z)-α-trans-bergamotol (18.1%), linalool (3.0%) and piperitenone oxide (2.9%). The best anti-bacterial</em><em> activity was observed for the methanol extract against Staphylococcus epidermidis with ZI (19.0 ± 0.47) mm and also against Proteus mirabilis with MIC value of 1.25 µg/mL.Investigation </em><em>of the samples on cell viability of HeLa cells showed good activity for the essential oil with an IC₅₀ </em><em>value of 5.2 µg/mL. Our results indicated that</em> <em><em>Teucrium </em></em><em>scordium</em><em> can be considered for further analyses as an effective and safe curing agent for cancer and pathogenic infection therapies.</em>