Volumetric and Viscometric Studies of Nucleosides, Nucleotides and Furanose Sugar in Aqueous Medium from 288.15 to 298.15K

Abstract

<em>Density (</em><em>r</em><em>/g cm^-3) and viscosity (</em><em>h</em><em>/10^-2gcm^-1s^-1=1centipoise,CP) of guanosine monophosphate (GMP) and adenosine triphosphate (ATP) referred to as nucleotide, and 2-deoxy adenosine (DOA) and thymidine (TMD) as nucleoside along with their integral furanose sugar, 2-deoxy ribose (DOR) from 0.0004 to 0.0014mol kg^-1solution have been measured at 288.15, 293.15 and 298.15K at atmospheric pressure. The </em><em>r</em><em> was fitted into the Masson and </em><em>h</em><em> in Jones-Dole equations</em><em>for apparent</em><em>molal volume </em><em> </em><em>(V</em><em>_f</em><em>/cm³mol</em><em>^-1</em><em>) </em><em> </em><em>and viscosity</em><em>coefficient</em><em>((</em><em>h</em><em>r-1)/m=B/kg mol</em><em>^-1</em><em>=10</em><em>³</em><em>gmol</em><em>^-1</em><em>) data. The V</em><em>_f</em><em>and </em><em>h</em><em> were</em><em>also regressed for</em><em>V</em><em>⁰</em><em>_f</em><em> and </em><em>h</em><em>⁰</em><em> values known as the limiting </em><em>constants </em><em>and </em><em>illustrate </em><em>solute-solvent </em><em>and </em><em>solute-solute</em><em>in teractions of systems. The apparent molal volume of their various integral units like adenine, guanine and thymine of nucleotides and nucleosides</em><em>are</em><em>estimated</em><em>by</em><em>V</em><em>⁰</em><em>_f</em><em>The</em><em>V</em><em>⁰</em><em>_f</em><em>h</em><em>⁰</em><em>and</em><em>B values have been used to elucidate the hydrophilic and hydrophobic interactions. The V</em><em>⁰</em><em>_f</em><em> values are negative over the whole range of the compositions which infer greater intermolecular forces and the biomolecules as water structure breakers.</em>