Functionalized Mesoporous Silica Nanoparticles as a Novel Antioxidant Delivery System

Abstract

<span style="font-size: 11pt; color: #000000; font-style: normal; font-variant: normal;"><em>Antioxidants have an important role in control and prevention of dangerous</em> <span style="font-size: 11pt; color: #000000; font-style: normal; font-variant: normal;"><em>diseases like cancers, but instability and high solubility of the antioxidants are</em> <span style="font-size: 11pt; color: #000000; font-style: normal; font-variant: normal;"><em>major challenges of pharmaceutical researchers. Thus, using a suitable carrier</em> <span style="font-size: 11pt; color: #000000; font-style: normal; font-variant: normal;"><em>for an antioxidant can enhance the antioxidant stability and protect it from</em> <span style="font-size: 11pt; color: #000000; font-style: normal; font-variant: normal;"><em>reacting with the other existing molecules in the blood circulation. Mesoporous</em> <span style="font-size: 11pt; color: #000000; font-style: normal; font-variant: normal;"><em>silica nanoparticles (MSNs) have been widely used as a carrier for therapeutic</em> <span style="font-size: 11pt; color: #000000; font-style: normal; font-variant: normal;"><em>applications because of their suitable biological properties. This study attempts</em> <span style="font-size: 11pt; color: #000000; font-style: normal; font-variant: normal;"><em>to improve the surface properties and increase antioxidant loading by</em> <span style="font-size: 11pt; color: #000000; font-style: normal; font-variant: normal;"><em>functionaliztion of MSNs with 3-aminopropyltriethoxysilane (AP-MSNs) via</em> <span style="font-size: 11pt; color: #000000; font-style: normal; font-variant: normal;"><em>post- synthesis grafting method. Synthesized nanoparticles were characterized</em> <span style="font-size: 11pt; color: #000000; font-style: normal; font-variant: normal;"><em>by Scanning electron microscopy (SEM), Zetasizer and Fourier transform</em> <span style="font-size: 11pt; color: #000000; font-style: normal; font-variant: normal;"><em>infrared spectroscopy (FTIR). Gallic acid (GA) was loaded into AP-MSNs. To</em> <span style="font-size: 11pt; color: #000000; font-style: normal; font-variant: normal;"><em>optimize GA loading capacity, two effective parameters: GA concentration and</em> <span style="font-size: 11pt; color: #000000; font-style: normal; font-variant: normal;"><em>embedding time were investigated. So different concentrations of GA in EtOH</em> <span style="font-size: 11pt; color: #000000; font-style: normal; font-variant: normal;"><em>(1-50 mg/mL) were prepared and sampling was done in 24 and 48 h. Results</em> <span style="font-size: 11pt; color: #000000; font-style: normal; font-variant: normal;"><em>showed that the best GA loading capacity was obtained at a concentration of</em> <span style="font-size: 11pt; color: #000000; font-style: normal; font-variant: normal;"><em>40 mg/mL in 48 h. The maximum GA loading capacity and entrapment</em> <span style="font-size: 11pt; color: #000000; font-style: normal; font-variant: normal;"><em>efficiency were obtained 46 and 20%, respectively, determined by</em> <span style="font-size: 11pt; color: #000000; font-style: normal; font-variant: normal;"><em>spectrophotometry and high-performance liquid chromatography (HPLC)</em> <span style="font-size: 11pt; color: #000000; font-style: normal; font-variant: normal;"><em>analysis.</em></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;" /><br class="Apple-interchange-newline" /></span>