Uranyle Complexes: synthesis, evaluation of biological activity

Abstract

In this research, some of the inorganic complexes of uranyl with N- donor ligands<br />were synthesized. Complexes were characteriezed by FT-IR and UV spectra, ¹HNMR,<br />¹³CNMR and some physical properties. The uranyl unit (UO2) is composed of a center of<br />uranium atom with the charge (+6) and two oxygen atom by forming two U=O double bonds.<br />The structure is linear (O=U=O, 180) and usually stable. So other ligands often coordinate to<br />the U atom in the plane perpendicularly to the O=U=O axis. The antitumor activity of some of<br />ligand and their complexes against a panel of human tumor cell lines (HT29: Haman colon<br />adenocarcinoma cell line T47D: human breast adenocarcinoma cell line) were determined by<br />MTT(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide) assay. These data<br />suggest that some of these compounds provide good models for the further design of potent<br />antitumor compounds.