Solvent-free One Pot Biginelli Method for Synthesis of new Dihydropyrimidinone compounds

Abstract

An effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl₂ as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yields, short reaction times for formation of the products and simple work-up are attractive features of this green protocol.