Simple and efficient Heterocyclization method for Synthesis of new pyrimido thiadiazine-3,7-diamine derivatives

Abstract

New 1,5-tetra alkyl methyl- phenyl-1H-pyrimido[4,5-e][1,3,4]thiadiazine-3,7-diamine were synthesized <em>via</em> the cyclo condensation of 2-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-2-methylhydrazine with phenylthioisothiocyanate and further replacement of chlorine atom on the seven number position of pyrimido[4, 5- <em>e</em>][1, 3, 4]thiadiazin by appropriate secondary amines in simple and efficient methods.