Synthesis of Some Quinazoline Derivatives Functionalized with3-Heterocycles Side Chain

Abstract

Utilization of benzoxazinone for synthesis quinazolinone derivatives with 3-heterocycle side chain. treatment of benzoxazinon <strong>1</strong> with cyano acetohydrazide or thionocarbohydrazide gave the quinazolinone derivatives <strong>2</strong> or <strong>12</strong>. quinazolinone <strong>2</strong> has been utilized as synthon for new pyridinone, oxazet, thiazole, thiazolidinone and quinazolinone derivatives. Thiosemicarbazide and thiosemicarbazone derivatives are synthesized from quinazolinone <strong>12</strong> by different route. The structures of the new compounds were established on the basis of IR, ¹HNMR, mass spectral data, and elemental analysis.