Synthesis of alkyl 2-(4-oxoquinazolin-3(4H)-yl) acrylate by nucleophilic additionof alkyl propiolates catalysed by Ph3P

Abstract

4-Hydroxyquinazoline undergoes neutral conditions with alkyl propiolates in the presence of triphenylphosphine (0.26g), and by α substituation the corresponding 2-(4-oxoquinazolin-3(4H)-yl acrylate was obtained in good yields.