P2O5/Al2O3 as an effieient catalyst for one-pot synthesis of polyhydroquinoline derivatives under solvent-free conditions

Abstract

The condensation of aromatic aldehydes, dimedone, ethylacetoacetate and ammonium acetate promoted by was Phosphorus pentoxide supported on alumina carried out under solvent-free conditions to afford corresponding polyhydroquinolinederivatives. This method provides several advantages including high yields, low reaction times, easy work up and little catalyst loading.