Volume 24, Issue 5
مرور بر اساس
ارسال های اخیر
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Detection of <i>csgA</i> gene in carbapenem-resistant <i>Acinetobacter baumannii</i> strains and targeting with <i>Ocimum sanctum</i> biocompounds
(Mashhad University of Medical Sciences, 2021-05-01)Objective(s): Carbapenem-resistant Acinetobacter baumannii (CRAB) is considered highly virulent due to csgA gene-mediated biofilm formation. The present study aimed to target the same gene, employing the antibiofilm effect ...
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<i>In vivo</i> murine breast cancer targeting by magnetic iron nanoparticles involving L. GG cytoplasmic fraction
(Mashhad University of Medical Sciences, 2021-05-01)Objective(s): Use of chemical anti-cancer drugs frequently creates serious side effects. However, probiotics are natural and treat different kinds of cancer without undesired effects.Materials and Methods: In this study, ...
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Sirtuin 3 deficiency promotes acute kidney injury induced by sepsis via mitochondrial dysfunction and apoptosis
(Mashhad University of Medical Sciences, 2021-05-01)Objective(s): To explore the regulation mechanism of Sirtuin 3 (SIRT3) on the mitochondrial function and apoptosis of acute kidney injury (AKI) in septic mice.Materials and Methods: The sepsis-induced AKI model was constructed ...
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<i>In vitro</i> identification of antimicrobial hemolytic lipopeptide from halotolerant <i>Bacillus</i> by Zymogram, FTIR, and GC mass analysis
(Mashhad University of Medical Sciences, 2021-05-01)Objective(s): The multi-drug resistant bacteria and clinical infections are some of the biggest global concerns, so new drugs are needed. Antimicrobial peptides and lipopeptides are new bioactive agents with great potential ...
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Effects of the diphenylheptane extract of <i>Alpinia officinarum</i> rhizomes on ethanol-induced gastric ulcers in mice
(Mashhad University of Medical Sciences, 2021-05-01)Objective(s): Experimental studies have revealed that Alpinia officinarum Hance (Zingiberaceae) exhibits a gastrointestinal protective effect. The present study aimed to investigate the effects of diphenylheptanes (DPHs) ...
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Gas chromatography-mass spectrometry profiling and analgesic, anti-inflammatory, antipyretic, and antihyperglycemic potentials of <i>Persea americana</i>
(Mashhad University of Medical Sciences, 2021-05-01)Objective(s): The present study determines the chemical constituents of Persea americana using gas chromatography-mass spectrometry (GC-MS) and its different activities. Materials and Methods: Air-dried powdered leaves of ...
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Quercetin protects islet β‑cells from oxidation-induced apoptosis via Sirt3 in T2DM
(Mashhad University of Medical Sciences, 2021-05-01)Objective(s): Sirt3 may regulate ROS production and might be involved in β‑cell apoptosis, which plays an important role in the progression of type 2 diabetes mellitus (T2DM). Quercetin is a potent anti-oxidative bioflavonoid, ...
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Antibacterial activity of honeys and potential synergism of honeys with antibiotics and alkaloid extract of <i>Sophora alopecuroides</i> plant against antibiotic-resistant Escherichia coli mutant
(Mashhad University of Medical Sciences, 2021-05-01)Objective(s): The increase in multidrug-resistant Escherichia coli strains with an overactivated AcrAB-TolC efflux pump has reduced the effectiveness of synthetic antibiotics, such as ciprofloxacin. The activity of this ...
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Role of the glutamatergic system of ventrolateral periaqueductal gray (vlPAG) in the cardiovascular responses in normal and hemorrhagic conditions in rats
(Mashhad University of Medical Sciences, 2021-05-01)Objective(s): Periaqueductal gray (PAG) is a mesencephalic area divided into four columns including ventrolateral periaqueductal gray (vlPAG). vlPAG plays a role in cardiovascular regulation during normal and hemorrhagic ...
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Dopaminergic agonist pramipexole improves memory and increases IL-10 production in LPS-challenged rats
(Mashhad University of Medical Sciences, 2021-05-01)Objective(s): A variety of cytokines are involved in cognitive functioning. Balance restoration between protective and degenerative neuro-inflammation is of great interest in newer therapeutic approaches. In the current ...
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Mesenchymal stem cells as professional actors in gastrointestinal cancer therapy: From Naïve to genetically modified
(Mashhad University of Medical Sciences, 2021-05-01)Considering the high incidence and mortality rate of gastrointestinal cancers (GIs) worldwide and partial success of the current available GI cancer treatments, there is a necessity to discover more effective approaches ...
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Biomedical features of flaxseed against different pathologic situations: A narrative review
(Mashhad University of Medical Sciences, 2021-05-01)Flaxseed is a plant that grows and is cultivated in more than 50 countries; the main flax producer countries are Canada, China, the United States, and India. The purpose of the present study was to overview the source, ...
