Histopathological and Biomechanical Study on the Effect of <i>Aftemisia sieberi</i> Extract on Experimental Skin Wound Healing in Rat

Abstract

Objective- To evaluate the effects of Artemisia sieberi extract on experimental dermal wounds healing. Design- Experimental study.Animals- 30 male Spragne-Dawly rats. Procedures- Two uniform 7 mm diameter skin defect were created on the back of each animal by skinpunch (total of 60 wounds). Then, the extract of the plant was applied once daily on half of the wounds forhistopathological and biomechanical examinations. Results- Artemisia sieberi extract caused a significant increase in the number of fibroblasts and capillarybuds and also significant decrease in the epithelial gap which showed the better formation of healing tissuein treatment group. On the other hand, the improvement of biomechanical indices in treatment group revealed a significant increase in tensile strength of the wounds. Conclusion and Clinical Relevance- It can be concluded that Artemisia sieberi is an effective herbalremedy in wound healing.