Volume 24, Issue 2
مرور بر اساس
ارسال های اخیر
-
Vitamin B12 and estradiol benzoate improve memory retrieval through activation of the hippocampal AKT, BDNF, and CREB proteins in a rat model of multiple sclerosis
(Mashhad University of Medical Sciences, 2021-02-01)Objective(s): Multiple sclerosis (MS) causes extensive damage in the hippocampus. Vitamin B12 (vit B12) and estradiol benzoate (EB) have the anti-inflammatory and re-myelination properties that make them proper in improvement ...
-
Prevention of cisplatin-induced nausea and vomiting by seabuckthorn (<i>Hippophae rhamnoides</i> L.) seed oil: Insights at the level of orexin-A in rats
(Mashhad University of Medical Sciences, 2021-02-01)Objective(s): Nausea and vomiting are perennial problems in cancer patients undergoing chemotherapy. Orexin-A (OXA) has been shown to regulate feeding and gastric motility. Seabuckthorn (Hippophae rhamnoides L.) seed oil ...
-
Sphingomyelin liposome bearing whole <i>Leishmania</i> lysate antigens induce strong Th2 immune response in BALB/c mice
(Mashhad University of Medical Sciences, 2021-02-01)Objective(s): Whole Leishmania lysate antigens (WLL) has been shown to be effective to tackle leishmaniasis in murine models. Although liposomes can be considered as promising vaccines, the activity of phospholipase-A (PLA) ...
-
Respiratory syncytial virus infection of microglia exacerbates SH-SY5Y neuronal cell injury by inducing the secretion of inflammatory cytokines: A Transwell <i>in vitro</i> study
(Mashhad University of Medical Sciences, 2021-02-01)Objective(s): To elucidate the mechanism of Respiratory Syncytial Virus (RSV) infection and central neuronal disease and to understand the role of microglia in neuronal injuries during RSV infection.Materials and Methods: ...
-
Preparation and immunological properties of a nanovaccine against <i>Pseudomonas aeruginosa</i> based on gold nanoparticles and detoxified lipopolysaccharide
(Mashhad University of Medical Sciences, 2021-02-01)Objective(s): Pseudomonas aeruginosa is one of the most important bacterial pathogens in immunocompromised patients, and the lipopolysaccharide (LPS) of this organism is a key factor in virulence and both innate and acquired ...
-
LILRA3 is related to monocyte-derived dendritic cell maturation and activation
(Mashhad University of Medical Sciences, 2021-02-01)Objective(s): Previously we reported functional leukocyte immunoglobulin-like receptor A3 (LILRA3) leads to susceptibility and sub-phenotypes of several autoimmune diseases. LILRA3 levels in blood serum and CD14+ monocytes ...
-
Identification of a novel homozygous mutation in the <i>DDR2</i> gene from a patient with spondylo-meta-epiphyseal dysplasia by whole exome sequencing
(Mashhad University of Medical Sciences, 2021-02-01)Objective(s): The spondylo-meta-epiphyseal dysplasia (SMED) short limbs-hand type is a rare autosomal recessive disease, which is characterized by premature calcification leading to severe disproportionate short stature ...
-
L-Carnitine ameliorates the liver by regulating alpha-SMA, iNOS, HSP90, HIF-1alpha, and RIP1 expressions of CCL4-toxic rats
(Mashhad University of Medical Sciences, 2021-02-01)Objective(s): Carbon tetrachloride (CCL4) toxicity triggers fibrosis, activating various mechanisms within the cell. We aimed to create damage with CCL4 and investigate the effectiveness of L-carnitine on the mechanisms ...
-
Comparative study of gavage and intraperitoneal administration of gamma-oryzanol in alleviation/attenuation in a rat animal model of renal ischemia/reperfusion-induced injury
(Mashhad University of Medical Sciences, 2021-02-01)Objective(s): Ischemia/reperfusion (I/R) is the leading cause of acute kidney injury. This study aimed to elucidate the reno-protective effect of gamma-oryzanol (GO) by comparing gavage and intraperitoneal (IP) administration ...
-
Cyanocobalamin improves memory impairment via inhibition of necrosis and apoptosis of hippocampal cell death after transient global ischemia/reperfusion
(Mashhad University of Medical Sciences, 2021-02-01)Objective(s): Brain ischemia/reperfusion (I/R) causes irreversible damage, particularly in the hippocampus. Cyanocobalamin (CNCbl) is known to be crucial for the proper operation of the nervous system. Vitamin B12 has been ...
-
Exercise alleviates cardiac remodelling in diabetic cardiomyopathy via the miR-486a-5p-Mst1 pathway
(Mashhad University of Medical Sciences, 2021-02-01)Objective(s): Physical exercise has emerged as an effective therapy to mitigate cardiac remodelling in diabetic cardiomyopathy (DCM). The results of our previous studies revealed mammalian sterile 20-like kinase 1 (Mst1) ...
-
Integron and its role in antimicrobial resistance: A literature review on some bacterial pathogens
(Mashhad University of Medical Sciences, 2021-02-01)In recent years, different acquired resistance mechanisms, including transposons, bacteriophages, plasmids, and integrons have been identified as involved in the spread of resistance genes in bacteria. The role of integrons ...
-
Alzheimer’s disease treatment: The share of herbal medicines
(Mashhad University of Medical Sciences, 2021-02-01)One of the most frequent forms of dementia in neurological disorders is Alzheimer's disease (AD). It is a chronic neurodegenerative disease characterized by impaired learning and memory. Pathological symptoms as extracellular ...
