Nano-TiO2 an Efficient, Clean and Eco-friendly Catalyst for Synthesis of Naphthoxazinone Derivatives as High Potent Antibacterial Agents

Abstract

Oxazines naturally occurs and synthetically exhibit wide-ranging biological activity. In this study, a highly practical and efficient of 1,2-dihydro-1-phenylnaphtho[1,2-e][1,3]oxazine-3-one derivatives was developed via a multi-component reaction of 2-naphthol, aldehydes and urea in the presence of nano-titanium oxide as solid, recyclable catalyst at one-pot and solvent-free conditions. These synthetic compounds 2a-e were evaluated as potential antibacterial agents. The structures of products were confirmed by spectral analysis FT-IR and ¹H NMR. The antibacterial activity of the compounds was screened against <em>Staphylococcus aureus </em>and <em>Escherichia coli.</em> These results showed that these compounds exhibited significant to moderate activities against both Gram (+) and Gram (-) organisms.