Design and performance investigation of electrospun PVA nanofibers containing core-shell nanostructures for anticancer drug delivery

Abstract

Objective: The purpose of this work was design and performance investigation of a nanocarrier based on magnetic nanofibers containing core-shell nanostructuresfor anticancerdrug delivery of daunorubicin (DAN) by measuring their drug release at different pH values. Methods: Fe3O4 nanoparticles and Fe3O4@SiO2core-shell nanostructures were synthesized through coprecipitation and Stöber methodrespectively. The composite nanofibers of polyvinyl alcohol containing core-shell nanostructures and anticancer drug of daunorubicinwere fabricated by electrospinning method.The nanostructures were characterized bySEM, XRD,VSM and FTIR techniques. The drug release was investigated by UV-Vis spectrophotometer at different pHs. Results: The results is shown that in vitro drug release at pH= 6.0 is promisingly more and faster than drug release at pH= 7.4. The fitted equation of release curves is corresponded to Peppas model. Conclusions: It can be concluded that the proposed nanocarrier is capable of responding to pH changes, that is an advantage in the targeted delivery of the drug. Also, this method has the advantages of magnetic sensitivity, high drug loading capacity and sustained release.