One-pot Multi-step Synthesis of some Aromatic Salicylaldoximes Using MgO Nanoparticles

Abstract

MgO nanopartticels (NP-MgO) in average size between 30—130 nm were prepared by sonochemistry method. Some phenols have been converted to ortho-hydroxybezaldehyd by ortho-formylation using MgO nanoparticles and (CH2O)n in xylene and subsequently treated with aqueous NH2OH.HCl, affording the corresponding aldoxime in a one-pot procedure. Moreover, this one-pot process, with two transformations, offers a number of advantages. In particular, the direct transformation of intermediates to the desired products reduces the time normally spent on isolation and purification.