Effects of essential oils of Thymus deanensis and Satureja bachtiarica on plasma lipoproteins in rats feeding with a fatty diet

Abstract

Background & Aim: Hyper lipidemy is one of the main factors in progressing cardiovascular diseases. Thymus deanensis celak and Satureja bachtiarica Bunge are medicinal herbs which are used in folklore medicine in Iran. In this research, hypolipidemic effects of essential oils of these herbs in rats fed with a fatty diet were investigated. Experimental: 40 male and femade adult rats (20 rats in each group) with 190 - 220 g weight were divided to five groups randomly (8 rats in each group). Experimental groups were 1) control, 2) control + fatty ration, 3) standard drug () + fatty ration, 4) T. deanensis (200 mg/kg) + fatty ration, and 5) S. bachtiarica (200 mg/kg) + fatty ration. At one week after starting special dietary ration, animal treated by the essential oils for three weeks. In final, serum and plasma were separated for measuring lipids and doing the other biochemical experiments. Results & Discussion: Results indicated that the essential oil of T. deanensis in rats fed with fatty dietary ration decreased level of low density lipoproteins (LDL) significantly (p ≤ 0.05). There was a significant difference in amount of triglycerides of blood serum in rats (p ≤ 0.05), The lowest and highest amounts of triglycerides obtained from T. deanensis and control + fatty ration groups, respectively. Recommended applications/industries: Results indicated the essential oil of T. deanensis had hypolipidemic effect in rats fed with a fatty diet.