Comparison of Antiphospholipid Antibodies between Preeclamptsia and Normal Pregnant Women

Abstract

Antiphospholipid antibodies (APLA) may be detected in normal pregnancies and also may cause thrombosis, recurrent fetal loss, placental infarction and preeclampsia. In the present study the possible differences in APLA titer between healthy pregnant women and preeclampsia cases without history of thrombosis was examined. The APLA titer in 50 healthy pregnant women with 50 preeclampsia cases without the history of thrombosis and autoimmune disease was compared. Pre-eclampcia is defined as hypertension ³140/90 mmHg after 20 weeks of gestation and proteinuria > 300mg/24h. IgG and IgM anticardiolipin antibodies were measured by immunoassay methods and Teclot kits for lupus-like anticoagulant antibodies were used. In normal pregnant women, 6% had lupus-like anticoagulant antibody, 12% had IgG anticardiolipin antibody, and 26% had IgM anticardiolipid antibodies. In preeclapsia, 8% lupus-like anticoagulant antibody, 4% had IgG anticardiolipin antibody, and 30% had IgM anticardiolipid antibodies. Despite the evidence of prothrombotic state during preeclampsia, it is unlikely that antiphospholipid antibodies represent as a risk factor for preeclampsia among women without the history of thrombosis or autoimmune diseases.Iran J Med Sci 2006; 31(1): 47-49. Keywords ● Antiphospholipid ● anticardiolipin ● anticoagulant ● antibody ● preeclampsia