Histopathological evidences for effect beneficial of Satureja hortensis extract on hepatic lesion by cadmium–induced in Rat

Abstract

Background & Aim:Cadmium is an important industrial and environmental pollutant. Cadmium is one of the most toxic and carcinogenic heavy metals to organisms. This heavy metal mainly distributes to the liver and kidney in humans and animal and, causing acute hepatic injury. Experimental: The ethanol extract of <em>Satureja hortensis</em> L. (Lamiaceae family), was evaluated for its activity against cadmium–induced in male Wister rats (150 – 180 g). The ethanol extract of <em>S. hortensis</em> (100 and 200 mg/kg/day for six weeks) was examined on serum bicochemical and hepatic histopathological characteristic of rats subcutaneously received with cadmium chloride (CdCl₂) at 3 mg/kg/day for six weeks. Results: The biochemical results indicated that aspartate transminase (AST) and alanine transaminase (ALT) significantly increased in serum by cadmium–induced. The liver histopathological results revealed that the ethanol extract of <em>S. hortensis</em> treatment at 200 mg/kg/day significantly reduced toxicity by cadmium–induced. The ethanol extract of <em>S. hortensis</em> prevents the cadmium–induced lesions in hepatic function. Recommended applications/industries: Known antioxidant, antimicrobial, antihepatotoxic, nephroprotective potentials of the extract of <em>S. hortensis</em> may be the mechanisms by which this plant protects animals against experimentally cadmium–induced.