The effect of Policosanol on decrease of cholesterol, triglyceride and the other lipid metabolite levels in blood of Wistar rats

Abstract

Background & Aim: Policosanol is a component from main alcohol groups with long-chain that extracted from cane sugar. In the present research, the effect of policosanol was investigated on decrease of lipid metabolite levels in blood of hypercholesterolemia rats. Experimental: A number of 32 male Wistar rats race with average weight of 250 g was divided into four groups including negative control group (<em>n</em>=8) that had normal diet, positive control and experimental groups I and II (<em>n</em>=8) with high cholesterol diet of 2% cholestroled, and respectively they received placebo and policosanol with concentrations 0.25 and 0.5 mg/day. After four weeks, following the treatment of animals and bloodletting, the biochemical traits such as cholesterol biochemical, triglyceride, and LDL-C and HDL-C factors were measured. Results & Discussion: The results showed that in experimental group (I) there was a significant decrease (<em>p</em><0.05) in the rate of cholesterol, LDL-C and triglyceride, and significant increase (<em>p</em><0.05) in HDL-C compared with control group. In experimental group II, there also was a significant decrease (<em>p</em><0.01) in the rate of cholesterol, LDL-C and triglyceride, and significant increase (<em>p</em><0.01) in HDL-C compared with control group. Industrial and practical recommendations: Policosanol can be an effective component in decreasing the rate of cholesterol, LDL-C and triglyceride and increasing HDL-C.