Effect of Cichorium intybus L. extracts and Kelussia oderatassima Mozaff. essential oil on toxic of organophosphouros insecticides in RAT

Abstract

Background & Aim: Organophosphates are frequently used as insecticides in households, in agricultural areas and veterinary, thus posing a risk for accidental dermal exposure or through inhalation. Acute organophosphate poisoning causes thousands of human mortalities each year in developing countries. Material & Methods: This study carried out to study an antitoxic effect of endemic Iranian medicinal plants agent against organophosphorus on rats. In order, anti-toxic effects of <em>Cichorium intybus</em> L. root ethanol extract and <em>Kelussia</em> <em>oderatassima</em> Mozaff. leaves essential oil on liver and kidney rat. This is an experimental study in 18 Wistar rats were randomly into 6 groups. After 24 hr fasting, normal saline was given to the first group, two and three groups received 200 and 400 mg/kg <em>Cichorium intybus</em> extract, four and five groups received 200 and 400 mg/kg <em>Kelussia oderatassima</em> essential oil and six groups received standard drug (Phenobarbital). Results & Discussion: The histopathological observation indicated that the lowest necrosis in kidney was group received 200 mg/kg <em>Kelussia</em> <em>oderatassima</em> essential oil and highest necrosis in kidney was groups received 200 and 400 mg/kg <em>Cichorium intybus</em> extract and standard drug. The histopathological observation indicated that standard drug and groups received 400 mg/kg <em>Cichorium intybus</em> extract and 200 mg/kg <em>Kelussia oderatassima</em> essential oil may protect liver against acute hepatotoxicity induced by Organophosphate insecticide. Also the highest of increased weight rats revealed group received 200 mg/kg <em>Kelussia oderatassima</em> essential oil. Conclusion: The results show that <em>Kelussia oderatassima</em> essential oil an antitoxic effect against organophosphrus on at.