Hypercholesterolemia Ameliorating Effect of Bangladeshi High Yield Variety Rice Bran Oil

Abstract

<strong>Background:</strong> Hypercholesterolemia led cardiovascular disease (CVD) complications are plaguing the globe. In the present study,Bangladesh Rice Research Institute (BRRI) high yield variety (HYV) rice named as BR5 was selected for extracting bran oil followed by fatty acid analysis and <em>in vivo</em> hypocholesterolemic effect of the extracted rice bran oil (RBO) for the sake of ameliorating CVD.<br /> <strong>Method: </strong>RBO was extracted using n-Hexane followed by fatty acid analysis and anti-hypocholesterolemic study on rats against soybean oil (SBO), mustard oil (MBO) and butter oil (BTO) followed by organ function tests. Study period was four weeks. Then the rats were killed, their blood was collected and serum biochemical parameters were analyzed using semi-auto analyzer.<br /> <strong>Results: </strong>Fattyacid analyses revealed BR5 was the best among the six HYVs of rice. Compared with the other edible oils, RBO derived from BR5 showed significantly increasing effect upon plasma total cholesterol and low density lipoprotein cholesterol lowering while high density lipoprotein cholesterol increasing. Toxicological studies showed no detrimental effect of BR5 derived RBO on cardiac, renal and hepatic functions.<br /> <strong>Conclusion: </strong>BR5 is a rich source of RBO that provides balanced fatty acid support and exerts hypocholesterolemic effects without any detectable side effects. Consumption of BR5 derived RBO would aid in CVD amelioration.