Manganese Ferrite Nanocomposite Modified Electrochemical Sensor for the Detection of Guanine and Uric Acid

Abstract

Manganese ferrite nanoparticles were produced by applying the combustion technique using the manganese acetate and ferric nitrate as the starting material. Analytical techniques like FESEM and TEM were utilized to characterize the synthesized materials. The typical size was observed in the range of 12 to 14 nm with a cubic structure. The synthesized material was used as an electrochemical sensor which was fabricated using the nanocomposite for the identification of guanine (GU) and uric acid (UA) (individually and in their mixture). The cyclic voltammeter and differential pulse voltammeter techniques were deployed to check the sensor activity of the modified electrode. Lower detection limit for GU and UA was found to be 400 nM and 450 nM, with linearity range 0.5 to 120 μM and 02 to 140 μM for GU and UA respectively. The electrochemical sensor developed in this method can be widely employed for the identification of GU and UA and analogs in biofluids or dosage forms.