IS THERE ANY RELATION BETWEEN CIRCULATING ENDOTHELIAL-LEUKOCYTE ADHESION MOLECULE -1 AND EXTENT OF CORONARY ARTERY INVOLVEMENTS IN MEN WITH ANGINA PECTORIS?

Abstract

Background- Selectins as a group of adhesion molecule arise from the surface of activated cell and involved for atherosclerotic plaque production.<br />Objective- To evaluate the relationship between Circulating Endothelial-Leukocyte adhesion molecule -1 (E-selectin) and the extent of coronary artery involvement in male Patients with coronary heart disease (CHD).<br />Methods- Participants were 103 male patients with symptoms of CHD. Patients underwent coronary angiography and according to angiography results they were divided to 80 patients with severe CHD and 23 with mild coronary involvements according to angiographic score. The Circulating E-selectin level was compared in both groups by ELISA method. Anova and analysis of covariant (ANCOVA) were used for evaluating possible association of E-selectin level and severity of coronary artery involvement by adjusting age, history of diabetes mellitus, hypertension, and dyslipidemia.<br />Results- The mean age of 103 male patients was 58.32±9.42 years. The E-selectin level was not significantly different in both groups with sever and minimal (CHD) (P=0.78). ANCOVA test could not show after significant association between E-selectin level and the extent of coronary artery involvement adjusting age (P=0.94) as well as history of diabetes mellitus, hypertension, and dyslepidemia respectively (P=0.43).<br />Conclusion- The circulating E-selectin level have no association with the severity of CHD in male patients.