The Assessment of Serum Apelin-12 Level in a Variety of Pulmonary Malignancies in Smokers

Abstract

<span><strong>Background: </strong><span>Apelin has recently been considered as an adipokine secreted from visceral fat. Apelin and its<br /><span>receptor exist in many tissues including lung and play significant roles in many physiological and<br /><span>pathological activities. However, serum level of apelin-12 is unknown in smokers and in various types of lung<br /><span>malignancies. Therefore, the amount of this hormone in non-patient smokers and the correlation of apelin<br /><span>serum level with the types of lung cancer in smokers afflicted with lung cancer are evaluated in this study.<br /><span><strong>Methods: </strong><span>The amount of serum apelin-12 was measured in 63 patients (59 smokers and 4 non-smokers) with<br /><span>the variety of lung cancer and 61 age- and sex-matched controls (30 smokers and 31 non-smokers) using<br /><span>enzyme-linked immunosorbent assay (ELISA) kit.<br /><span><strong>Findings: </strong><span>The amount of serum apelin-12 in non-patient smokers (2142.20 ± 843.61 ng/l) was significantly<br /><span>higher than healthy non-smokers (800.39 ± 336.01 ng/l, P < 0.05), and in the variety of lung malignancies,<br /><span>the amount of serum apelin-12 was 2205.54 ± 187.31 ng/l in patients with squamous cell carcinoma (SCC)<br /><span>which was a significant increase compared to 1088.00 ± 136.52 ng/l in adenocarcinoma, 797.25 ± 88.69 ng/l<br /><span>in small cell carcinoma, and 1000.37 ± 62.87 ng/l in other malignancies of lung.<br /><span><strong>Conclusion: </strong><span>The meaningful increase in apelin-12 levels of non-patient smokers can be considered as a risk<br /><span>factor for outbreaking of lung SCC in these people. Therefore, apelin-12 may be considered as a target in<br /><span>controlling lung SCC.</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><br /><br class="Apple-interchange-newline" /></span></span></span></span></span>