Hydro-alcoholic extract of the root of Prangos ferulacea (L.) Lindl can improve serum glucose and lipids in alloxan-induced diabetic rats

Abstract

Objectives: Diabetes mellitusmanifests itself in a wide variety of complications and the symptoms of this disease are multifactorial. Previousstudies proved that this disease is directly related to hyperglycemia and hyperlipidemia. The aim of this study was to investigate the hypoglycemic and hypolipidemic effects of hydroalcoholic extract of <em>Prangos frulacea</em> (L.)Lindlin alloxan-induced diabetic rats. Materials and Methods: Forty female Wistar rats with body weight of 200±20 g were randomly divided into five groups with eight rats per group. Diabetes was induced in rats by alloxan monohydrate at dose of 120 mg/kg body weight (BW) injected intraperitoneally. Hydro-alcoholic extract of the root and leaves with stems of <em>P. frulacea </em>at 100 mg/kg BW were given orally to diabetic rats daily for 4 weeks. Result: Diabetic rats (D) exhibited a significant (p<0.05) increase in the levels of the serum glucose, Total Cholesterol (TC), Triglycerides (TG), and LDL in comparison with the control group whereas their BW and serum HDL levels were decreased. In diabetic rats treated by root extract of <em>P. frulacea, </em>these parameters were reversed to the normal levels compared with diabetic group. Conclusion: According to the results obtained, it was concluded that Root´s hydro-alcoholic extract of <em>P. frulacea </em>can be used in diabetics for the purpose of glucose and lipid profile reduction.