Neuro-pharmacological effects of Crinum zeylanicum in mice

Abstract

Objectives: The aim of present study was to evaluate some effects of <em>Crinum zeylanicum</em> (<em>C. zeylanicum</em>) on central nervous system. Materials and Methods: <em>C. zeylanicum</em> methanolic bulb extract (250-1000 mg/kg orally), 2 mg chlorpromazine and 4 mg diazepam /kg body weight intraperitoneally respectively were tested in mice using Irwin test, pentobarbitone-induced sleep test, spontaneous motor activity, apomorphine-induced stereotype behaviour, and rota-rod performance. Results: The <em>C.</em> <em>zeylanicum</em> bulb extract significantly and dose-dependently decreased apomorphine-induced hyperactivity in mice (p<0.001). The Irwin test revealed dose-dependent central depressant effect of the extract, shortened (p<0.05-0.01) the onset of sleep and prolonged the duration of sleep. The extract produced significant (p<0.05-0.001) and dose- dependent reduction in spontaneous motor activity and apomorphine-induced stereotype behaviours in mice. The extract had no effect on performance of mice on rotarod. Conclusion: The results suggest that the extract may possess sedative principles with potential neuroleptic properties.