Study of cytotoxic properties of Rosa damascena extract in human cervix carcinoma cell line

Abstract

Objective: Cancer is a major health problem worldwide and current therapies for cancer are often limited by short-term efficacy due to drug resistance. There has been much interest in the use of naturally occurring compounds with chemo-preventive and chemotherapeutic properties in the treatment of cancers. <em>Rose</em> is one of the most important groups of ornamental plants which their fruits and flowers are used in a wide variety of foods, nutritional products and different traditional medicines. Material and methods: In this study cytotoxic effect of Rosa damascena extract was evaluated on HeLa cell line. HeLa cells were cultured in DMEM medium and incubated with different concentrations of <em>Rosa damascene</em> (<em>R. damascene</em>) extract. Cell viability was quantitated by MTT assay. Results: <em>Rosa</em> decreased cell viability in malignant cells in a concentration and time dependent manner. The IC50 values against HeLa were determined as 2135, 1540 and 305.1 µg.ml^-1 after 24, 48 and 72h, respectively. Conclusion: It might be concluded that <em>R. damascena</em> could cause cell death in HeLa cells which could be also considered as a promising chemotherapeutic agent in cancer treatment in future.