A New Method for the Synthesis of New Derivatives of “1,3- diaryl-2-n-azaphenalene and n-acyl-1,3-diaryl-2-N-azephenylene” by Using Nano catalyst and Analyzing Antibacterial Activity of Structures

Abstract

In this research, synthesized well derivatives of 1,3-diaryl-2-N-azaphenalene and N-acyl-1.3-diaryl-<br />2-N- azaphenalene as a macromolecule in the presence of nanoparticles (Fe3O4 coated with L-Arginine)<br />as a magnetic Nano catalyst in a one-pot reaction of compounds 7.2-Naphthalene diol, aldehydes,<br />ammonium derivatives (ammonium acetate or ammonium hydro phosphates) and solvent (water<br />and alcohol) with high yield and short reaction times, economical and simple workup. In this study,<br />apart from the innovation in the synthesis of a macromolecule, the antibacterial activity of these<br />compounds was evaluated for the first time. The reaction was doe under very moderate conditions<br />at room temperature. The chemical structures of all synthesized compounds were determined using<br />infrared, 1H NMR and 13C NMR spectroscopies. After the production of nanoparticles, the structure of<br />the obtained nanoparticles was characterized via Fourier transform infrared spectroscopy (IR) and field<br />emission scanning electron microscopy (FE-SEM). The results demonstrated that the average size of<br />the synthesized magnetite nanoparticles is about 21 nm. The heterogeneous catalyst used was easily<br />separated magnetically and reused without any significant loss of catalytic activity and magnetism.<br />Eventually, antibacterial activity of the synthesized compounds was investigated by Escherichia coli<br />(ATCC: 25922) and Pseudomonas aeruginosa (ATCC: 27853) as gram negative bacteria, Staphylococcus<br />epidermidis (ATCC: 14990) and Staphylococcus aureus (ATCC: 29213) as gram positive bacteria. Some<br />of these products exhibit significant antibacterial activity.