Biological Application of Layered Double Hydroxides in Drug Delivery Systems

Abstract

This review focuses on the extensive study of different layered double hydroxides (LDHs)<br />nanostructures and also their biological and physicochemical (in vitro) properties to encapsulate<br />and deliver drugs with a recognized pharmacokinetic profile in a sustained/modified manner for<br />better remedial efficacy contrasted to the corresponding conventional treatments using different<br />drugs. LDHs known as hydrotalcite like compounds possess positive charges due to isomorphic<br />substitutions, which are counterbalanced by hydrated exchangeable anions located in the interlayer<br />region. Some of the active ingredient molecules can be intercalated into the inner region of the LDHs<br />through ionic bonding, hydrogen bonding or van der Waals interaction to form nanohybrids, which<br />are more potent for their protection and controlled‐release. In addition, this composite material<br />exhibits a selective release toward cancer cells and good biocompatibility with normal cells, which<br />would guarantee its practical applications in cancer therapy.