Synthesis of Chitosan Nanoparticles Loaded with Antibiotics as Drug Carriers and the Study of Antibacterial Activity

Abstract

In recent years, there is a lot of interest in synthesis of nanostructures as carriers for drug delivery.<br />These structures are considered as a highly effective drug delivery system due to controlling drug<br />release, protecting the pharmaceutical molecule, and environmentally friendly. In this study, the<br />synthesis of chitosan nanoparticles was carried out by chemical method. The nanoparticles size was<br />measured by dynamic light scattering (DLS). Also, it was used from atomic absorption spectrometry<br />(AAS), FTIR and transmission electron microscopy (TEM) to confirm the loading of antibiotic onto<br />nanoparticles and to calculate the percentage of the drug loaded. In addition, it was used for<br />clarithromycin as antibiotic. The antibacterial activity was studied by the disc-diffusion method<br />and the effect of different concentrations of the drug in nano-carriers were investigated and it was<br />determined the optimum antibacterial activity of drug nanocarrier was happened in concentration<br />0.6 gr/10 ml.