Synthesis and anti-microbial activities of azomethine and aminomethyl phenol derivatives

Abstract

A series of azomethine and aminomethyl phenol derivatives has been synthesized and characterized by mass, IR, and NMR spectral techniques.In<em> vitro</em> antimicrobial activities of all these compounds were evaluated against different gram-positive and gram-negative bacterial and fungal strains by measuring zone of inhibition using agar diffusion method. Results of antimicrobial screening indicated that the compound <strong>4a</strong> was the most active antimicrobial agent (100 µg/mL). The compounds <strong>3a</strong>, <strong>4e</strong>, <strong>4f</strong> were exhibited best in<em> vitro</em> anti-microbial activity against the gram positive bacterial strains such as <em>Bacillus subtilis, Micrococcus luteus </em>and gram negativebacterialstrain <em>Salmonella typhi </em>andfungalstrain <em>Candida albicans.</em>